BRENDA - Enzyme Database
show all sequences of 1.5.3.7

L-Pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species

Mihalik, S.J.; Rhead, W.J.; J. Biol. Chem. 264, 2509-2517 (1989)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
additional information
activity is maximal when FAD, phenazine ethosulfate and glycerol are included in the assay
Oryctolagus cuniculus
Application
Application
Commentary
Organism
medicine
L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders
Macacine alphaherpesvirus 1
medicine
L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
antimycin A
-
Oryctolagus cuniculus
L-proline
-
Oryctolagus cuniculus
phenazine ethosulfate
-
Macacine alphaherpesvirus 1
rotenone
-
Oryctolagus cuniculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.74
-
L-pipecolic acid
-
Oryctolagus cuniculus
4.2
-
L-pipecolic acid
-
Macacine alphaherpesvirus 1
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
soluble fraction
Oryctolagus cuniculus
5739
-
peroxisome
membrane-associated
Macacine alphaherpesvirus 1
5777
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-pipecolate + O2
Oryctolagus cuniculus
-
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
Oryctolagus cuniculus
?
L-pipecolate + O2
Macacine alphaherpesvirus 1
-
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
Macacine alphaherpesvirus 1
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Macacine alphaherpesvirus 1
-
cynomolgus monkey
-
Oryctolagus cuniculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Oryctolagus cuniculus
-
heart
-
Oryctolagus cuniculus
-
kidney
highest activity in the kidney cortex
Macacine alphaherpesvirus 1
-
kidney
highest activity in the kidney cortex
Oryctolagus cuniculus
-
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-pipecolate + O2
-
392477
Oryctolagus cuniculus
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
-
-
?
L-pipecolate + O2
-
392477
Macacine alphaherpesvirus 1
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
-
-
?
L-pipecolate + O2
-
392477
Oryctolagus cuniculus
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
392477
Oryctolagus cuniculus
?
L-pipecolate + O2
-
392477
Macacine alphaherpesvirus 1
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
392477
Macacine alphaherpesvirus 1
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Macacine alphaherpesvirus 1
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Macacine alphaherpesvirus 1
FAD
-
Oryctolagus cuniculus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
10
-
L-proline
-
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
additional information
activity is maximal when FAD, phenazine ethosulfate and glycerol are included in the assay
Oryctolagus cuniculus
Application (protein specific)
Application
Commentary
Organism
medicine
L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders
Macacine alphaherpesvirus 1
medicine
L-pipecolic oxidase activity is deficient in patients with peroxisome biogenesis disorders
Oryctolagus cuniculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Macacine alphaherpesvirus 1
FAD
-
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
antimycin A
-
Oryctolagus cuniculus
L-proline
-
Oryctolagus cuniculus
phenazine ethosulfate
-
Macacine alphaherpesvirus 1
rotenone
-
Oryctolagus cuniculus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
10
-
L-proline
-
Oryctolagus cuniculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.74
-
L-pipecolic acid
-
Oryctolagus cuniculus
4.2
-
L-pipecolic acid
-
Macacine alphaherpesvirus 1
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
soluble fraction
Oryctolagus cuniculus
5739
-
peroxisome
membrane-associated
Macacine alphaherpesvirus 1
5777
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-pipecolate + O2
Oryctolagus cuniculus
-
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
Oryctolagus cuniculus
?
L-pipecolate + O2
Macacine alphaherpesvirus 1
-
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
Macacine alphaherpesvirus 1
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Oryctolagus cuniculus
-
heart
-
Oryctolagus cuniculus
-
kidney
highest activity in the kidney cortex
Macacine alphaherpesvirus 1
-
kidney
highest activity in the kidney cortex
Oryctolagus cuniculus
-
liver
-
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-pipecolate + O2
-
392477
Oryctolagus cuniculus
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
-
-
?
L-pipecolate + O2
-
392477
Macacine alphaherpesvirus 1
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
-
-
?
L-pipecolate + O2
-
392477
Oryctolagus cuniculus
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
392477
Oryctolagus cuniculus
?
L-pipecolate + O2
-
392477
Macacine alphaherpesvirus 1
2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
the product reacts with water to form 2-aminoadipate 6-semialdehyde
392477
Macacine alphaherpesvirus 1
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Macacine alphaherpesvirus 1
Other publictions for EC 1.5.3.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742960
Natarajan
Evidence for pipecolate oxida ...
Homo sapiens
J. Cell. Biochem.
118
1678-1688
2017
-
-
-
-
-
-
-
-
1
-
-
2
-
2
-
-
-
-
-
1
-
-
4
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
4
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
743036
Posset
Understanding cerebral L-lysi ...
Mus musculus
J. Inherit. Metab. Dis.
38
265-272
2015
-
-
-
-
-
-
-
-
1
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656324
Yoshida
Characterization of two fructo ...
Schizosaccharomyces pombe
J. Biosci. Bioeng.
97
278-280
2004
-
-
1
-
-
-
-
2
-
-
2
1
-
1
-
-
1
-
-
-
1
-
4
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
2
-
-
2
1
-
-
-
1
-
-
1
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
392467
Naranjo
Conversion of pipecolic acid i ...
Penicillium chrysogenum
J. Bacteriol.
183
7165-7172
2001
-
-
1
-
-
-
-
-
-
-
-
1
-
7
-
-
-
-
-
-
1
-
1
-
1
-
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1
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1
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1
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-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
392469
Dodt
The human L-pipecolic acid oxi ...
Homo sapiens
Cell Biochem. Biophys.
32
313-316
2000
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392470
Ijlst
Molecular cloning and expressi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
270
1101-1105
2000
-
1
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
392471
Zabriskie
-
Mechanism-based inactivity of ...
Macaca mulatta
Bioorg. Med. Chem. Lett.
7
457-462
1997
-
-
-
-
-
-
2
1
1
-
1
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
2
1
1
1
-
1
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392472
Zabriskie
-
Stereochemical course of the o ...
Macaca mulatta
J. Am. Chem. Soc.
119
6446-6447
1997
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
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-
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-
1
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-
1
-
-
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-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392473
Rao
L-Pipecolic acid oxidation in ...
Rattus norvegicus
Biochim. Biophys. Acta
1164
29-35
1993
2
-
-
-
-
-
2
-
2
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
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-
-
1
-
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2
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-
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-
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2
-
-
2
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
392475
Rao
L-Pipecolic acid metabolism in ...
Homo sapiens
Biochim. Biophys. Acta
1038
295-299
1990
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
2
-
-
1
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2
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1
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2
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392476
Wanders
L-pipecolate oxidase: a distin ...
Homo sapiens
Biochem. Biophys. Res. Commun.
164
550-555
1989
-
1
-
-
-
-
-
-
2
-
-
1
-
2
-
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-
1
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1
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1
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2
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392477
Mihalik
L-Pipecolic acid oxidation in ...
Macacine alphaherpesvirus 1, Oryctolagus cuniculus
J. Biol. Chem.
264
2509-2517
1989
1
2
-
-
-
-
4
2
2
-
-
2
-
2
-
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-
-
5
-
-
4
-
-
-
-
-
1
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2
1
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1
2
-
2
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4
1
2
2
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2
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5
-
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4
-
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-
-
1
-
-
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-
-
-
-
-
-
392478
Kinzel
Lysine biosynthesis in Rhodoto ...
Rhodotorula glutinis
J. Bacteriol.
151
1073-1077
1982
-
-
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5
1
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1
1
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1
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2
2
1
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2
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1
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1
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5
1
1
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1
1
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2
2
1
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2
-
1
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