Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of isoform NOX5-S or NF-kappaB1 p50 by their small interfering RNA significantly inhibits acid-induced cyclooxygenase COX2 expression and prostaglandin PGE2 production in SEG-1 cells. In a Barrett's cell line overexpressing isoform NOX5-S, inhibitor of kappaB is significantly reduced, and luciferase activity increased when these Barrett' s cells are transfected with a plasmid carrying NF-kappaB fused to luciferase. Overexpression of NOX5-S in Barretts cells significantly increases H2O2 production,cyclooxygenase COX2 expression, PGE2 production, and thymidine incorporation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform Nox5-S | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | muscle biopsies of patients with Barrett's esophagus | Homo sapiens | - |
SEG-1 cell | Barretts esophageal adenocarcinoma cells | Homo sapiens | - |