Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | Homo sapiens | - |
NADP+ + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
8505C cell | - |
Homo sapiens | - |
BCPAP cell | - |
Homo sapiens | - |
papillary thyroid carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Homo sapiens | NADP+ + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 65000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
NADPH oxidase | - |
Homo sapiens |
Nox4 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the BRAFV600E oncogene upregulates the enzyme NOX4 via TGF-beta1 signaling pathway in papillary thyroid cancer cell line | up |
General Information | Comment | Organism |
---|---|---|
physiological function | NADPH oxidase NOX4 is a critical mediator of BRAF(V600E)-induced downregulation of the sodium/iodide symporter in papillary thyroid carcinomas | Homo sapiens |