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Literature summary for 1.6.3.5 extracted from

  • Wu, Y.; Wang, L.; Deng, D.; Zhang, Q.; Liu, W.
    Renalase protects against renal fibrosis by inhibiting the activation of the ERK signaling pathways (2017), Int. J. Mol. Sci., 18, 855 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.5

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5VYX0
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Rattus norvegicus Q5U2W9
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Source Tissue

Source Tissue Comment Organism Textmining
HK-2 cell proximal renal tubular epithelial cell Homo sapiens
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Synonyms

Synonyms Comment Organism
RnlS
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 Homo sapiens
RnlS
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function in HK-2 cells, renalase inhibits TGF-1-mediated upregulation of alpha-smooth muscle actin and downregulation of E-cadherin. Increased levels of phospho-extracellular regulated protein kinases (p-ERK1/2) in TGF-1-stimulated cells are reversed by renalase cotreatment. When ERK1 is overexpressed, the inhibition of TGF-1-induced EMT and fibrosis mediated by renalase is attenuated Homo sapiens
physiological function in rats with complete unilateral ureteral obstruction, the expression of renalase is markedly downregulated and adenoviral-mediated expression of renalase significantly attenuates renal interstitial fibrosis Rattus norvegicus