Literature summary for 1.6.3.5 extracted from

Gao, Y.; Wang, M.; Guo, X.; Hu, J.; Chen, T.M.; Finn, S.M.B.; Lacy, J.; Kunstman, J.W.; Cha, C.H.; Bellin, M.D.; Robert, M.E.; Desir, G.V.; Gorelick, F.S.
Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma (2021), PLoS ONE, 16, e0250539 .

Search for more literature for 1.6.3.5

Application

Application	Comment	Organism
medicine	in chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples and is also widely present in pancreatic ductal adenocarcinoma precursor lesions and pancreatic ductal adenocarcinoma tissue. Among 240 patients with pancreatic ductal adenocarcinoma, elevated plasma renalase levels are associated with worse tumor characteristics, including greater angiolymphatic invasion and greater node positive disease. Overall survival is worse in patients with high plasma renalase levels. Renalase levels also predict whether patients with locally advanced/borderline resectable pancreatic ductal adenocarcinoma undergo resection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5VYX0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	little to no renalase is detected by histochemistry in the normal pancreatic head in the absence of abdominal trauma. In chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	little to no renalase is detected by histochemistry in the normal pancreatic head in the absence of abdominal trauma. In chronic pancreatitis, renalase immunoreactivity localizes to peri-acinar spindle-shaped cells in some samples and is also widely present in pancreatic ductal adenocarcinoma precursor lesions and pancreatic ductal adenocarcinoma tissue. Among 240 patients with pancreatic ductal adenocarcinoma, elevated plasma renalase levels are associated with worse tumor characteristics, including greater angiolymphatic invasion and greater node positive disease. Overall survival is worse in patients with high plasma renalase levels. Renalase levels also predict whether patients with locally advanced/borderline resectable pancreatic ductal adenocarcinoma undergo resection	Homo sapiens

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Release 2023.1 (January 2023)