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Literature summary for extracted from

  • Benson, A.M.
    Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice (1993), Biochem. Pharmacol., 46, 1217-1221.
    View publication on PubMed


Inhibitors Comment Organism Structure
additional information not inhibited by dicoumarol Mus musculus
additional information not inhibited by 0.015 mM dicoumarol Rattus norvegicus


Localization Comment Organism GeneOntology No. Textmining
Rattus norvegicus 5829


Organism UniProt Comment Textmining
Mus musculus
Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
partially Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitroquinoline N-oxide + NAD(P)H + H+ NADH is preferred, 15% activity with NADPH Rattus norvegicus 4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O
4-nitroquinoline N-oxide + NAD(P)H + H+ strong preference for NADH Mus musculus 4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O