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Literature summary for 1.8.1.2 extracted from

  • Tavolieri, A.M.; Murray, D.T.; Askenasy, I.; Pennington, J.M.; McGarry, L.; Stanley, C.B.; Stroupe, M.E.
    NADPH-dependent sulfite reductase flavoprotein adopts an extended conformation unique to this diflavin reductase (2019), J. Struct. Biol., 205, 170-179 .
    View publication on PubMed
Search for more literature for 1.8.1.2

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sulfite + 3 NADPH + 3 H+ Escherichia coli
-
 hydrogen sulfide + 3 NADP+ + 3 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli W8SX42 W8SX42: SiRFP, sulfite reductase [NADPH] flavoprotein alpha-component (cysJ)
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sulfite + 3 NADPH + 3 H+
-
 Escherichia coli hydrogen sulfide + 3 NADP+ + 3 H2O
-
 ?
sulfite + 3 NADPH + 3 H+ the electron transfer occurs via multiple pathways, bypassing the need for electrons to move intra-molecularly from the NADH to the FAD to the FMN and then in cis to SiRHP. In this way, SiR effectively raises the local concentration of electrons relative to SiRHP active sites to facilitate the full six electron reduction of SO32- to S2- Escherichia coli hydrogen sulfide + 3 NADP+ + 3 H2O
-
 ?

Subunits

Subunits Comment Organism
dodecamer
-
 Escherichia coli

Synonyms

Synonyms Comment Organism
NADPH-dependent sulfite reductase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein. The electron transfer occurs via multiple pathways, bypassing the need for electrons to move intra-molecularly from the NADH to the FAD to the FMN and then in cis to SiRHP. In this way, SiR effectively raises the local concentration of electrons relative to SiRHP active sites to facilitate the full six electron reduction of SO32- to S2- Escherichia coli