Any feedback?
Literature summary for 1.8.1.4 extracted from
- Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases (1989), Arch. Biochem. Biophys., 268, 409-425.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 49690 | - |
x * 49690, calculation from nucleotide sequence | Sus scrofa |
| 51274 | - |
x * 51274, calculation from nucleotide sequence | Escherichia coli |
| 54000 | - |
x * 54000, SDS-PAGE | Geobacillus stearothermophilus |
| 54000 | - |
x * 54000, SDS-PAGE | Ascaris suum |
| 55000 | - |
x * 55000, SDS-PAGE | Bos taurus |
| 56000 | - |
x * 56000, SDS-PAGE | Rattus norvegicus |
| 56000 | - |
x * 56000, SDS-PAGE | Azotobacter vinelandii |
| 56000 | - |
x * 56000, enzyme from liver enzyme | Rattus norvegicus |
| 58000 | - |
x * 58000, SDS-PAGE | Halobacterium salinarum |
| 58000 | - |
x * 58000, enzyme from heart, SDS-PAGE | Rattus norvegicus |
| 59000 | - |
x * 59000, SDS-PAGE | Pisum sativum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces pastorianus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? |  |
| additional information | Bacillus subtilis | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Escherichia coli | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Sus scrofa | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Bos taurus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Geobacillus stearothermophilus | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Pisum sativum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Pseudomonas aeruginosa | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Pseudomonas putida | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Halobacterium salinarum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Ascaris suum | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
| additional information | Azotobacter vinelandii | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ascaris suum | - |
dihydrolipoamide dehydrogenase E3 | - |
| Azotobacter vinelandii | - |
dihydrolipoamide dehydrogenase E3 | - |
| Bacillus subtilis | - |
dihydrolipoamide dehydrogenase E3 | - |
| Bos taurus | - |
- |
- |
| Escherichia coli | - |
K-12 | - |
| Escherichia coli | - |
dihydrolipoamide dehydrogenase E3 | - |
| Geobacillus stearothermophilus | - |
dihydrolipoamide dehydrogenase E3 | - |
| Halobacterium salinarum | - |
dihydrolipoamide dehydrogenase E3 | - |
| Homo sapiens | - |
- |
- |
| Pisum sativum | - |
dihydrolipoamide dehydrogenase E3 | - |
| Pseudomonas aeruginosa | - |
dihydrolipoamide dehydrogenase E3 | - |
| Pseudomonas putida | - |
dihydrolipoamide dehydrogenase E3 | - |
| Rattus norvegicus | - |
dihydrolipoamide dehydrogenase E3 | - |
| Saccharomyces cerevisiae | - |
dihydrolipoamide dehydrogenase E3 | - |
| Saccharomyces pastorianus | - |
dihydrolipoamide dehydrogenase E3 | - |
| Sus scrofa | - |
dihydrolipoamide dehydrogenase E3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| kidney | - |
Bos taurus | - |
| leaf | - |
Pisum sativum | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| muscle | - |
Ascaris suum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Saccharomyces pastorianus | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Bacillus subtilis | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Escherichia coli | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Homo sapiens | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Rattus norvegicus | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Sus scrofa | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Saccharomyces cerevisiae | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Bos taurus | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Geobacillus stearothermophilus | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Pisum sativum | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Pseudomonas aeruginosa | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Pseudomonas putida | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Halobacterium salinarum | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Ascaris suum | lipoamide + NADH | - |
? | |
| dihydrolipoamide + NAD+ | - |
Azotobacter vinelandii | lipoamide + NADH | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces pastorianus | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bacillus subtilis | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Escherichia coli | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Sus scrofa | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bos taurus | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Geobacillus stearothermophilus | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pisum sativum | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas aeruginosa | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas putida | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Halobacterium salinarum | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Ascaris suum | ? | - |
? | |
| additional information | the enzyme is a component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Azotobacter vinelandii | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Saccharomyces pastorianus |
| ? | - |
Homo sapiens |
| ? | x * 54000, SDS-PAGE | Geobacillus stearothermophilus |
| ? | x * 54000, SDS-PAGE | Ascaris suum |
| ? | x * 56000, SDS-PAGE | Rattus norvegicus |
| ? | x * 56000, SDS-PAGE | Azotobacter vinelandii |
| ? | x * 55000, SDS-PAGE | Bos taurus |
| ? | x * 58000, SDS-PAGE | Halobacterium salinarum |
| ? | x * 59000, SDS-PAGE | Pisum sativum |
| ? | x * 58000, enzyme from heart, SDS-PAGE | Rattus norvegicus |
| ? | x * 56000, enzyme from liver enzyme | Rattus norvegicus |
| ? | x * 49690, calculation from nucleotide sequence | Sus scrofa |
| ? | x * 51274, calculation from nucleotide sequence | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces pastorianus |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bacillus subtilis |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Escherichia coli |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Homo sapiens |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Rattus norvegicus |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Sus scrofa |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Saccharomyces cerevisiae |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Bos taurus |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Geobacillus stearothermophilus |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pisum sativum |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas aeruginosa |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Pseudomonas putida |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Halobacterium salinarum |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Ascaris suum |
| dihydrolipoamide dehydrogenase E3 | common component of the three 2-oxoacid dehydrogenase complexes oxidizing pyruvate, 2-oxoglutarate, and the branched-chain 2-oxo acids | Azotobacter vinelandii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Saccharomyces pastorianus | |
| NAD+ | - |
Bacillus subtilis | |
| NAD+ | - |
Escherichia coli | |
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Rattus norvegicus | |
| NAD+ | - |
Sus scrofa | |
| NAD+ | - |
Saccharomyces cerevisiae | |
| NAD+ | - |
Bos taurus | |
| NAD+ | - |
Geobacillus stearothermophilus | |
| NAD+ | - |
Pisum sativum | |
| NAD+ | - |
Pseudomonas aeruginosa | |
| NAD+ | - |
Pseudomonas putida | |
| NAD+ | - |
Halobacterium salinarum | |
| NAD+ | - |
Ascaris suum | |
| NAD+ | - |
Azotobacter vinelandii | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
