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Literature summary for 1.8.1.7 extracted from
- Molecular and functional characterization of a mitochondrial glutathione reductase homolog from redlip mullet (Liza haematocheila) Disclosing its antioxidant properties in the fish immune response mechanism (2020), Dev. Comp. Immunol., 113, 103785 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Planiliza haematocheilus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55430 | - |
calculated from sequence | Planiliza haematocheilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione disulfide + NADPH + H+ | Planiliza haematocheilus | - |
2 glutathione + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Planiliza haematocheilus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | highest mRNA expression of mitochondrial isoform of Liza haematocheila glutathione reductase is observed in the gill tissue under normal physiological conditions | Planiliza haematocheilus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione disulfide + NADPH + H+ | - |
Planiliza haematocheilus | 2 glutathione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione reductase | - |
Planiliza haematocheilus |
| GSHR | - |
Planiliza haematocheilus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Planiliza haematocheilus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 50 | 30°C: about 50% of maximal activity, 50°C: about 70% of maximal activity | Planiliza haematocheilus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Planiliza haematocheilus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 9 | pH 6.0: about 60% of maximal activity, pH 9.0: about 30% of maximal activity | Planiliza haematocheilus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Planiliza haematocheilus | highest mRNA expression of mitochondrial isoform of Liza haematocheila glutathione reductase is observed in the gill tissue under normal physiological conditions. Following pathogenic challenges, the transcription level is upregulated in a time-dependent manner in the gill and liver tissues, which may modulate the immune reaction against pathogens | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | phylogenetic analysis demonstrated the closest evolutionary relationship between mitochondrial isoform of Liza haematocheila glutathione reductase and other fish mitochondrial isoforms of glutathione reductase | Planiliza haematocheilus |
| physiological function | the enzyme has profound effects on modulating the immune reaction in fish to sustain precise redox homeostasis | Planiliza haematocheilus |
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