Application | Comment | Organism |
---|---|---|
medicine | - |
Escherichia coli |
medicine | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloned and expressed in Escherichia coli HMS174(DE3)/pCC12 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3'-dideoxy-2',3'-didehydro-carbocyclic glycinamide ribonucleotide | - |
Homo sapiens | |
2',3'-dideoxy-carbocyclic glycinamide ribonucleotide | - |
Homo sapiens | |
5'-phosphonate carbocyclic glycinamide ribonucleotide | - |
Homo sapiens | |
5,10-dideazatetrahydrofolate | - |
Escherichia coli | |
5,10-dideazatetrahydrofolate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
beta-glycinamide ribonucleotide | - |
Homo sapiens | |
0.0036 | - |
carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | |
0.0101 | - |
beta-glycinamide ribonucleotide | - |
Gallus gallus | |
0.0369 | - |
carbocyclic beta-glycinamide ribonucleotide | - |
Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Gallus gallus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Escherichia coli | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Gallus gallus | - |
chicken | - |
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme, expressed in E. coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Escherichia coli | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide | - |
Gallus gallus | tetrahydrofolate + formyl glycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | tetrahydrofolate + formyl glycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + O-phosphonate carbocyclic glycinamide ribonucleotide | - |
Homo sapiens | tetrahydrofolate + O-phosphonate-ribosyl-N-formylglycinamide | - |
? | |
additional information | - |
Gallus gallus | ? | - |
? | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | alpha-glycinamide ribonucleotide and glycinamide ribonucleotide nucleoside are neither substrates for no inhibitors | Homo sapiens | ? | - |
? |