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Literature summary for 2.1.2.2 extracted from

  • Batool, S.; Nawaz, M.S.; Mushtaq, G.; Parvaiz, F.; Kamal, M.A.
    In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA (2017), Saudi J. Biol. Sci., 24, 1155-1161 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.2.2

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine PY873 Homo sapiens
2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline PY899 Homo sapiens
5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)-isophthalic acid iDIA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide Homo sapiens
-
 tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22102
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide
-
 Homo sapiens tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide
-
 ?

Synonyms

Synonyms Comment Organism
GART
-
 Homo sapiens
GARTfase
-
 Homo sapiens
glycinamide ribonucleotide formyltransferase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0067
-
 2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine pH and temperature not specified in the publication Homo sapiens
0.02754
-
 2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline pH and temperature not specified in the publication Homo sapiens
0.04218
-
 5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)-isophthalic acid pH and temperature not specified in the publication Homo sapiens