KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.058 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.082 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.099 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.12 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.17 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.18 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.27 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.29 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.66 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.73 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.75 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-erythrose 4-phosphate + D-xylulose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
? | - |
r | |
D-erythrose 4-phosphate + D-xylulose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | - |
? | - |
r | |
D-ribose 5-phosphate + D-xylulose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r | |
D-ribose 5-phosphate + D-xylulose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | - |
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r | |
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
r | |
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | - |
D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | A0A0F6B484 and A0A0F6B483 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | A0A0F6B4M5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | A0A0F6B6H7 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | A0A0F6B484 and A0A0F6B483 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | A0A0F6B4M5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | A0A0F6B6H7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-erythrose 4-phosphate + D-xylulose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
r | |
D-erythrose 4-phosphate + D-xylulose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | ? | - |
r | |
D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r | |
D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r | |
additional information | isoform TktA is responsible for more than 88% of the transketolase activity in wild type cells | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
- |
|
additional information | isoform TktA is responsible for more than 88% of the transketolase activity in wild type cells | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | ? | - |
- |
|
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
r | |
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s | D-ribose 5-phosphate + D-xylulose 5-phosphate | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 34000, isoform TktC, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
? | x * 72000, isoform TktA, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
? | x * 73000, isoform TktB, SDS-PAGE | Salmonella enterica subsp. enterica serovar Typhimurium |
Synonyms | Comment | Organism |
---|---|---|
STM14_2885 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
STM14_2886 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
TktA | isoform | Salmonella enterica subsp. enterica serovar Typhimurium |
TktB | isoform | Salmonella enterica subsp. enterica serovar Typhimurium |
TKTc | isoform | Salmonella enterica subsp. enterica serovar Typhimurium |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
671 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
816 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
1350 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
1390 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
52500 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
67100 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
71400 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
78500 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
86500 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
95400 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
104000 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
131000 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
malfunction | transketolase-deficient Salmonella enterica Typhimurium can grow with glucose, but not ribose, as the sole carbon source | Salmonella enterica subsp. enterica serovar Typhimurium |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5580 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
10800 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
23200 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
60700 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
102000 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
106000 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
131000 | - |
D-ribose 5-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
269000 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
299000 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
422000 | - |
D-xylulose 5-phosphate | with excess D-erythrose 4-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
477000 | - |
D-xylulose 5-phosphate | with excess D-ribose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium | |
1050000 | - |
D-erythrose 4-phosphate | with excess D-xylose 5-phosphate as cosubstrate, at pH 7.5 and 37°C | Salmonella enterica subsp. enterica serovar Typhimurium |