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Literature summary for 2.3.1.107 extracted from

  • Pham, T.; Nguyen, T.; Bui, T.; Nguyen, H.; Nguyen, T.; Le, V.; Chu, H.
    Agrobacterium-mediated transformation of the CrDAT gene and selection of transgenic periwinkle lines with a high vincristine accumulation (2019), J. Hortic. Sci. Biotechnol., 94, 591-598 .
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Application

Application Comment Organism
drug development vincristine and vinblastine are secondary metabolites from Catharanthus roseus with very high pharmacological value that are used in treating cancer. However, these compounds are synthesised in Catharanthus roseus plants with very low content. The vincristine contents of four transgenic lines expressing the CrDAT gene are increased from 162.59% to 247.76% compared with the non-transgenic plants Catharanthus roseus

Cloned(Commentary)

Cloned (Comment) Organism
the CrDAT transgene is transferred into Catharanthus roseus by Agrobacterium-mediated transformation and generated transgenic periwinkle lines with an increase in vincristine accumulation. The Catharanthus roseus DAT gene is introduced into Catharanthus roseus plants and it ias confirmed that CrDAT is successfully transferred into the genome of periwinkle plants and efficiently translated to synthesise recombinant DAT protein Catharanthus roseus

Organism

Organism UniProt Comment Textmining
Catharanthus roseus Q9ZTK5
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General Information

General Information Comment Organism
physiological function key enzyme that catalyses the last reaction of vindoline biosynthesis to form vinblastine and vincristine Catharanthus roseus