Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae | Aspergillus terreus |
Protein Variants | Comment | Organism |
---|---|---|
C216A | mutant without catalytic activity | Aspergillus terreus |
H939A | mutant with catalytic activity | Aspergillus terreus |
additional information | deletion of one of the 6-methylsalicylic acid synthase domains ketosynthase, acyltransferase, dehydratase, ketoreductase, or acyl carrier protein results in a lost of catalytic activity | Aspergillus terreus |
S1761A | mutant without catalytic activity | Aspergillus terreus |
S667A | mutant without catalytic activity | Aspergillus terreus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
190000 | - |
- |
Penicillium griseofulvum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus terreus | - |
- |
- |
Penicillium griseofulvum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-CoA + NADPH | - |
Aspergillus terreus | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? | |
acetyl-CoA + malonyl-CoA + NADPH | - |
Penicillium griseofulvum | 6-methylsalicylate + CoA + CO2 + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | every subunit of 6-methylsalicylic acid synthase from Aspergillus terreus consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domain, proposed from deletion mutant analyses | Aspergillus terreus |
More | 6-methylsalicylic acid synthase from Penicillium patulum consist of ketosynthase (KS), acyltransferase (AT), dehydratase (DH), ketoreductase (KR), and acyl carrier protein (ACP) domains | Penicillium griseofulvum |
Synonyms | Comment | Organism |
---|---|---|
6-methylsalicylic acid synthase | - |
Aspergillus terreus |
6-methylsalicylic acid synthase | - |
Penicillium griseofulvum |
6-MSA | - |
Penicillium griseofulvum |
ATX | 6-methylsalicylic acid synthase from Aspergillus terreus | Aspergillus terreus |
iPKS | 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. | Aspergillus terreus |
iPKS | 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. | Penicillium griseofulvum |
iterative type I polyketide synthase | 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. | Aspergillus terreus |
iterative type I polyketide synthase | 6-methylsalicylic acid synthase belongs to the iterative type I polyketide synthases (iPKSs), which consist of ketosynthase (KS), acyltransferase (AT), and acyl carrier protein (ACP) domains as a minimum, with additional domains such as ketoreductase (KR), methyltransferase (MeT), and Claisen cyclase (CYC), all on single polypeptides. | Penicillium griseofulvum |