Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + N-acetylneuraminic acid | Homo sapiens | - |
CoA + N-acetyl-O-acetyl-neuraminate | the 9-O-acetyl neuraminic acid is the main product, but small amounts of 7-O-acetylated neuraminic acid are also detected, oligo-O-acetylated species are 5-N-acetyl-8,9-di-O-acetylneuraminic acid and 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, acids, but neither 5-N-acetyl-7,8-di-O-acetylneuraminic acid nor 5-N-acetyl-7,9-di-O-acetylneuraminic acid are formed, in microsomes, a migrase is involved catalysing the rapid migration of O-acetyl groups along the glycerol side chain, subsequently followed by the transfer of another acetyl group, facilitating the formation of 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, overview | ? | |
acetyl-CoA + N-acetylneuraminic acid | Homo sapiens | the level of free cytosolic Neu5,9Ac2 in human colon is regulated by the relative activity of the cytosolic sialate-O-acetylesterase | CoA + N-acetyl-O-acetyl-neuraminate | mono- and oligoacetylated products, overview | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | mucosa | Homo sapiens | - |
colorectal cancer cell | the relative level of O-acetylated sialic acids and of enzyme activity is decreased in the mucosa from colorectal carcinoma patients compared to the level healthy colon individuals | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative analysis of sialic acids formed in resection margins and colorectal carcinoma, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + CMP-N-acetylneuraminic acid | free acids or proteins as substrates | Homo sapiens | CoA + CMP-N-acetyl-9-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + CMP-N-acetylneuraminic acid | free acids or proteins as substrates | Homo sapiens | CoA + CMP-N-acetyl-7-O-acetyl-neuraminate | - |
? | |
acetyl-CoA + N-acetylneuraminic acid | - |
Homo sapiens | CoA + N-acetyl-O-acetyl-neuraminate | the 9-O-acetyl neuraminic acid is the main product, but small amounts of 7-O-acetylated neuraminic acid are also detected, oligo-O-acetylated species are 5-N-acetyl-8,9-di-O-acetylneuraminic acid and 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, acids, but neither 5-N-acetyl-7,8-di-O-acetylneuraminic acid nor 5-N-acetyl-7,9-di-O-acetylneuraminic acid are formed, in microsomes, a migrase is involved catalysing the rapid migration of O-acetyl groups along the glycerol side chain, subsequently followed by the transfer of another acetyl group, facilitating the formation of 5-N-acetyl-7,8,9-tri-O-acetylneuraminic acid, overview | ? | |
acetyl-CoA + N-acetylneuraminic acid | the level of free cytosolic Neu5,9Ac2 in human colon is regulated by the relative activity of the cytosolic sialate-O-acetylesterase | Homo sapiens | CoA + N-acetyl-O-acetyl-neuraminate | mono- and oligoacetylated products, overview | ? | |
additional information | the O-acetyl groups at C7 show the ability to migrate to C9 during extended periods of storage | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OAT | - |
Homo sapiens |
sialate-7(9)-O-acetyltransferase | - |
Homo sapiens |
sialate-O-acetyltransferase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |