Activating Compound | Comment | Organism | Structure |
---|---|---|---|
methylated histone | stimulates interaction of NuA4 complex with histone | Saccharomyces cerevisiae | |
NuA4 | cooperation with the NuA4 complex to enhance its functions but independent contribution to acetylation | Saccharomyces cerevisiae | |
SAGA | cooperation with the Gcn5 complex to enhance its functions but independent contribution to acetylation | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
L254P | esa1 mutant (reduced histone H4 acetylation) at 36°C (restrictive temperature) is sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) but shows little effect at 30°C (permissive temperature), gene length dependent defects in transcription | Saccharomyces cerevisiae |
additional information | double mutant esa1/gcn5 at 36°C is very sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) and shows littler but still strong effect at 30°C (permissive temperature), gene length dependent defects in transcription | Saccharomyces cerevisiae |
additional information | gcn5 deletion mutant (reduced H3 acetylation) at 36°C (restrictive temperature) is very sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) but shows less effect at 30°C (permissive temperature), gene length dependent defects in transcription | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | Saccharomyces cerevisiae | - |
CoA + acetylhistone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
wild-type strain BY4741 and deletion derivatives | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | - |
Saccharomyces cerevisiae | CoA + acetylhistone | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Esa1 | - |
Saccharomyces cerevisiae |
Gcn5 | - |
Saccharomyces cerevisiae |
H4 lysine acetyltransferase | - |
Saccharomyces cerevisiae |
KAT | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | Esa1 mediates increased H4 acetylation and enhanced chromatin remodeling complex RSC occupancy and histone eviction in coding sequences and stimulates the rate of transcription elongation by polymerase II | Saccharomyces cerevisiae |