Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-dodecylmalonate | compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4. Compound inhibits the acetylation of all the other H3 and H4 lysines, with the exception of residue K8Ac of histone H4 | Homo sapiens | |
diethyl 2-pentadecylidenemalonate | compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-dodecylmalonate | compound induces hyperacetylation of specific lysine residues of histone H3, in particular residues K9 and K18, and raises the level of pan-acetylated H4. Compound inhibits the acetylation of all the other H3 and H4 lysines, with the exception of residue K8Ac of histone H4 | Homo sapiens | |
2-tridecylmalonate | inhibition of the acetylation of histone H3 residuesK9/K18, being practically inactive in all the other assays | Homo sapiens | |
2-undecylmalonate | compound exhibits a significant inhibition of the acetylation of almost any lysine residue explored, with the sole exception of residue K8 of H4. Compound reduces the level of K5Ac of H4 and, more markedly, K16Ac of H4 | Homo sapiens | |
3-pentadecylidenepentane-2,4-dione | inhibition of the acetylation of histone H3 residuesK9/K14, being practically inactive in all the other assays | Homo sapiens | |
diethyl 2-tetradecylidenemalonate | compound exhibits a significant inhibition of the acetylation of almost any lysine residue explored, with the sole exception of residue K8 of H4. Compound reduces the level of K5Ac of H4 and, more markedly, K16Ac of H4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U-937 cell | - |
Homo sapiens | - |