Cloned (Comment) | Organism |
---|---|
functional ectopic overexpression of human serotonin N-acetyltransferase under the constitutive ubiquitin promoter in transgenic Oryza sativa cv. Dongjin seedlings using Agrobacterium-mediated gene transformation leading to elevated synthesis of N-acetylserotonin and melatonin in the transgenic rice plants, phenotype, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. Leaves of transgenic lines S9 and S10 contain approximately 2.5fold and 1.9fold more chlorophyll, respectively, than those of the wild type | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + serotonin | Homo sapiens | - |
CoA + N-acetylserotonin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + serotonin | - |
Homo sapiens | CoA + N-acetylserotonin | - |
? | |
acetyl-CoA + tryptamine | - |
Homo sapiens | CoA + N-acetyltryptamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serotonin N-acetyltransferase | - |
Homo sapiens |
SNA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | serotonin N-acetyltransferase is a rate-limiting enzyme in melatonin biosynthesis in vertebrates | Homo sapiens |
physiological function | serotonin N-acetyltransferase is responsible for the production of N-acetylserotonin, an intermediate of melatonin biosynthesis. Melatonin, i.e. N-acetyl-5-methoxytryptamine, has multiple functions in vertebrates, including the regulation of circadian rhythms and photoperiodism. Plant melatonin is involved in cold stress | Homo sapiens |