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Literature summary for 2.3.3.8 extracted from
- Discovery of allosteric inhibition of human ATP-citrate lyase (2019), Trends Pharmacol. Sci., 40, 364-366 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| full structure of human ACLY homotetramer in ternary complex with the inhibitor and ADP with an overall resolution of 3.67 A | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methyl 3-chloro-5-(N-(4,6-difluoro-[1,1'-biphenyl]-3-yl)sulfamoyl)-4-hydroxybenzoate | i.e. NDI-091143, allosteric inhibition | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + citrate + CoA | Homo sapiens | the enzyme links glycolysis to lipid metabolism | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P53396 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + citrate + CoA | - |
Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
| ATP + citrate + CoA | the enzyme links glycolysis to lipid metabolism | Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACLY | - |
Homo sapiens |
| ATP-citrate lyase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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