Application | Comment | Organism |
---|---|---|
medicine | fucosyltransferase IV overexpression promotes cell proliferation, increases the expression of proliferating cell nuclear antigen and augments Lewis Y expression to trigger neoplastic cell proliferation, fucosyltransferase IV may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in A-431 cells cells, two stable FUT-4 cell lines A431-FUT4-1 and A431-FUT4-2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22083 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAcbeta1-R | - |
Homo sapiens | GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-R | Lewis Y antigen, increased expression in cancer cells | ? |
Synonyms | Comment | Organism |
---|---|---|
fucosyltransferase IV | - |
Homo sapiens |