Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gallic acid | 80-90% inhibition at 4-5 mM, mixed-type inhibition in vitro | Streptococcus mutans | |
additional information | aqueous plant extracts from wood sticks of Acacia arabica, Azadirachta indica, Pongamia pinnata, and Salvadora persica are inhibitory. 5 mg Phenolic content in aqueous extracts of chewing stem sticks produce 35-40% inhibition of the enzyme activity, best inhibition at 7-7.5 for the phenolic compounds, and at pH 5.0-6.0 for plant extracts | Streptococcus mutans | |
syringic acid | 48% inhibition at 5 mM, mixed-type inhibition in vitro | Streptococcus mutans | |
Tannic acid | 80% inhibition at 0.2 mM, mixed-type inhibition in vitro | Streptococcus mutans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Streptococcus mutans | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sucrose + [(1->6)-alpha-D-glucosyl]n | Streptococcus mutans | - |
D-fructose + [(1->6)-alpha-D-glucosyl]n+1 | - |
? | |
sucrose + [(1->6)-alpha-D-glucosyl]n | Streptococcus mutans MTCC 890 | - |
D-fructose + [(1->6)-alpha-D-glucosyl]n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus mutans | - |
- |
- |
Streptococcus mutans MTCC 890 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from cell-free extracts by gel filtration | Streptococcus mutans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme shows hydrolytic and glucosyl transferase activities with sucrose | Streptococcus mutans | ? | - |
? | |
additional information | the enzyme shows hydrolytic and glucosyl transferase activities with sucrose | Streptococcus mutans MTCC 890 | ? | - |
? | |
sucrose + [(1->6)-alpha-D-glucosyl]n | - |
Streptococcus mutans | D-fructose + [(1->6)-alpha-D-glucosyl]n+1 | - |
? | |
sucrose + [(1->6)-alpha-D-glucosyl]n | - |
Streptococcus mutans MTCC 890 | D-fructose + [(1->6)-alpha-D-glucosyl]n+1 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Streptococcus mutans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Streptococcus mutans |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.35 | - |
Tannic acid | pH 6.8, 37°C | Streptococcus mutans | |
1.6 | - |
gallic acid | pH 6.8, 37°C | Streptococcus mutans | |
1.94 | - |
syringic acid | pH 6.8, 37°C | Streptococcus mutans |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is responsible for sucrose metabolism exhibiting both hydrolysis and glucosyl transferase activities | Streptococcus mutans |
physiological function | Streptococcus mutans causes dental caries in humans using sucrose for its growth | Streptococcus mutans |