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Literature summary for 2.4.2.14 extracted from
- In silico analysis of the amido phosphoribosyltransferase inhibition by PY873, PY899 and a derivative of isophthalic acid (2013), Invest. New Drugs, 31, 1355-1363.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine | PY873 | Homo sapiens |  |
| 2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline | PY899 | Homo sapiens | |
| 5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)isophthalic acid | - |
Homo sapiens | |
| AMP | - |
Homo sapiens | |
| cAMP | competitive inhibitor | Homo sapiens | |
| cGMP | competitive inhibitor | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate | Homo sapiens | - |
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q06203 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate | - |
Homo sapiens | L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| amido phosphoribosyltransferase | - |
Homo sapiens |
| APRT | - |
Homo sapiens |
| glutamine phosphoribosylpyrophosphate amidotransferase | - |
Homo sapiens |
| GPAT | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00131 | - |
AMP | pH and temperature not specified in the publication | Homo sapiens | |
| 0.00331 | - |
2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline | pH and temperature not specified in the publication | Homo sapiens | |
| 0.02327 | - |
2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.1167 | - |
5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)isophthalic acid | pH and temperature not specified in the publication | Homo sapiens | |
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