Application | Comment | Organism |
---|---|---|
medicine | tumor-associated macrophages that express thymidine phosphorylase may be a good target for chermotherapy of thymidine phosphorylase positive solid tumors | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
enzyme complexed with TPI | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-O-tritylinosine | - |
Homo sapiens | |
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride | - |
Homo sapiens | |
7-deazaxanthine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | Homo sapiens | the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymidine + phosphate | the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors | Homo sapiens | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gliostatin | - |
Homo sapiens |
PD-ECGF | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000002 | - |
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl] uracil hydrochloride | - |
Homo sapiens |