Application | Comment | Organism |
---|---|---|
medicine | inhibition of protein farnesyltransferase with influence for oncogenesis, potential target for treatment of cancer | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
desloratadine | - |
Rattus norvegicus | |
econazole | - |
Rattus norvegicus | |
loratadine | - |
Rattus norvegicus | |
miconazole | - |
Rattus norvegicus | |
rupatadine | - |
Rattus norvegicus | |
ubenimex | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + N-dansyl-GCVLS | assay at pH 7.5, 30°C | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFTase | - |
Rattus norvegicus |
protein farnesyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0133 | - |
- |
Rattus norvegicus | loratadine | |
0.0189 | - |
- |
Rattus norvegicus | miconazole | |
0.0233 | - |
- |
Rattus norvegicus | econazole | |
0.076 | - |
- |
Rattus norvegicus | rupatadine | |
0.1 | - |
value above | Rattus norvegicus | desloratadine | |
0.2 | - |
value above | Rattus norvegicus | ubenimex |