Cloned (Comment) | Organism |
---|---|
gene kptA, encoded in an operon-like cluster with genes encoding RNA polymerase, RNA ligase, and the Hen1/Pnkp RNA repairsystem reported to repair ribotoxin-degraded tRNAs in vitro | Catenulispora acidiphila |
gene kptA, genomic organization, comparisons | Fusobacterium nucleatum subsp. nucleatum |
gene kptA, genomic organization, comparisons | Herpetosiphon aurantiacus |
gene kptA, genomic organization, comparisons | Sebaldella termitidis |
gene kptA, genomic organization, comparisons | Agrobacterium tumefaciens |
gene kptA, genomic organization, comparisons | Brachyspira hyodysenteriae |
gene kptA, genomic organization, comparisons | Deinococcus radiodurans |
gene kptA, genomic organization, comparisons | Deinococcus deserti |
gene kptA, genomic organization, comparisons | Deinococcus gobiensis |
gene kptA, genomic organization, comparisons | Delftia acidovorans |
gene kptA, genomic organization, comparisons, the gene kpta neighborhood includes the genes coding for: (i) the enzyme Nam phosphoribo-syltransferase (NadV), involved in the recycling to NAD of Nam, thepyridine product of the KptA-catalyzed reaction, (ii) the orthologue of the yeast ADPR-1-P phosphatase, implicated in the conversionto ADPR of the adenylylic product, (iii) the enzyme ADPR diphosphatase (ADPRP), responsible for ADPR hydrolysis to AMPand R5P, and (iv) the enzyme PRPP synthetase, which catalyzes PRPP formation from ATP and ribose 5-phosphate | Flavobacterium johnsoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-phospho-[ligated tRNA] + NAD+ | Saccharomyces cerevisiae | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Fusobacterium nucleatum subsp. nucleatum | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Herpetosiphon aurantiacus | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Sebaldella termitidis | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Catenulispora acidiphila | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Flavobacterium johnsoniae | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Agrobacterium tumefaciens | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Brachyspira hyodysenteriae | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus radiodurans | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus deserti | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus gobiensis | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Delftia acidovorans | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Delftia acidovorans DSM 14801 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Agrobacterium tumefaciens C58 / ATCC 33970 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Brachyspira hyodysenteriae ATCC 49526 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Herpetosiphon aurantiacus DSM 785 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus gobiensis DSM 21396 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus radiodurans ATCC 13939 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Deinococcus deserti DSM 17065 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | Sebaldella termitidis ATCC 33386 | - |
mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agrobacterium tumefaciens | Q8U9Z2 | gene kptA | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | Q8U9Z2 | gene kptA | - |
Brachyspira hyodysenteriae | A0A3B6VB17 | gene kptA | - |
Brachyspira hyodysenteriae ATCC 49526 | A0A3B6VB17 | gene kptA | - |
Catenulispora acidiphila | C7QAQ2 | gene kptA | - |
Deinococcus deserti | C1CZ01 | gene kptA | - |
Deinococcus deserti DSM 17065 | C1CZ01 | gene kptA | - |
Deinococcus gobiensis | H8GTD5 | gene kptA | - |
Deinococcus gobiensis DSM 21396 | H8GTD5 | gene kptA | - |
Deinococcus radiodurans | Q9RRR1 | gene kptA | - |
Deinococcus radiodurans ATCC 13939 | Q9RRR1 | gene kptA | - |
Delftia acidovorans | A9C0S5 | gene kptA | - |
Delftia acidovorans DSM 14801 | A9C0S5 | gene kptA | - |
Flavobacterium johnsoniae | A5FLZ4 | gene kptA | - |
Fusobacterium nucleatum subsp. nucleatum | Q8R5N7 | gene kptA | - |
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847 | Q8R5N7 | gene kptA | - |
Herpetosiphon aurantiacus | A9B356 | gene kptA | - |
Herpetosiphon aurantiacus DSM 785 | A9B356 | gene kptA | - |
Saccharomyces cerevisiae | - |
gene kptA | - |
Sebaldella termitidis | D1APE3 | gene kptA | - |
Sebaldella termitidis ATCC 33386 | D1APE3 | gene kptA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-phospho-[ligated tRNA] + NAD+ | - |
Saccharomyces cerevisiae | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Fusobacterium nucleatum subsp. nucleatum | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Herpetosiphon aurantiacus | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Sebaldella termitidis | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Catenulispora acidiphila | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Flavobacterium johnsoniae | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Agrobacterium tumefaciens | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Brachyspira hyodysenteriae | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus radiodurans | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus deserti | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus gobiensis | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Delftia acidovorans | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Delftia acidovorans DSM 14801 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Agrobacterium tumefaciens C58 / ATCC 33970 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Brachyspira hyodysenteriae ATCC 49526 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Herpetosiphon aurantiacus DSM 785 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus gobiensis DSM 21396 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus radiodurans ATCC 13939 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Deinococcus deserti DSM 17065 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? | |
2'-phospho-[ligated tRNA] + NAD+ | - |
Sebaldella termitidis ATCC 33386 | mature tRNA + ADP-ribose 1'',2''-phosphate + nicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KptA | - |
Saccharomyces cerevisiae |
KptA | - |
Fusobacterium nucleatum subsp. nucleatum |
KptA | - |
Herpetosiphon aurantiacus |
KptA | - |
Sebaldella termitidis |
KptA | - |
Catenulispora acidiphila |
KptA | - |
Flavobacterium johnsoniae |
KptA | - |
Agrobacterium tumefaciens |
KptA | - |
Brachyspira hyodysenteriae |
KptA | - |
Deinococcus radiodurans |
KptA | - |
Deinococcus deserti |
KptA | - |
Deinococcus gobiensis |
KptA | - |
Delftia acidovorans |
NAD-dependent RNA 2'-phosphotransferase | - |
Saccharomyces cerevisiae |
NAD-dependent RNA 2'-phosphotransferase | - |
Fusobacterium nucleatum subsp. nucleatum |
NAD-dependent RNA 2'-phosphotransferase | - |
Herpetosiphon aurantiacus |
NAD-dependent RNA 2'-phosphotransferase | - |
Sebaldella termitidis |
NAD-dependent RNA 2'-phosphotransferase | - |
Catenulispora acidiphila |
NAD-dependent RNA 2'-phosphotransferase | - |
Flavobacterium johnsoniae |
NAD-dependent RNA 2'-phosphotransferase | - |
Agrobacterium tumefaciens |
NAD-dependent RNA 2'-phosphotransferase | - |
Brachyspira hyodysenteriae |
NAD-dependent RNA 2'-phosphotransferase | - |
Deinococcus radiodurans |
NAD-dependent RNA 2'-phosphotransferase | - |
Deinococcus deserti |
NAD-dependent RNA 2'-phosphotransferase | - |
Deinococcus gobiensis |
NAD-dependent RNA 2'-phosphotransferase | - |
Delftia acidovorans |
RNA 2'-phosphotransferase | - |
Saccharomyces cerevisiae |
RNA 2'-phosphotransferase | - |
Fusobacterium nucleatum subsp. nucleatum |
RNA 2'-phosphotransferase | - |
Herpetosiphon aurantiacus |
RNA 2'-phosphotransferase | - |
Sebaldella termitidis |
RNA 2'-phosphotransferase | - |
Catenulispora acidiphila |
RNA 2'-phosphotransferase | - |
Flavobacterium johnsoniae |
RNA 2'-phosphotransferase | - |
Agrobacterium tumefaciens |
RNA 2'-phosphotransferase | - |
Brachyspira hyodysenteriae |
RNA 2'-phosphotransferase | - |
Deinococcus radiodurans |
RNA 2'-phosphotransferase | - |
Deinococcus deserti |
RNA 2'-phosphotransferase | - |
Deinococcus gobiensis |
RNA 2'-phosphotransferase | - |
Delftia acidovorans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Saccharomyces cerevisiae | |
NAD+ | - |
Fusobacterium nucleatum subsp. nucleatum | |
NAD+ | - |
Herpetosiphon aurantiacus | |
NAD+ | - |
Sebaldella termitidis | |
NAD+ | - |
Catenulispora acidiphila | |
NAD+ | - |
Flavobacterium johnsoniae | |
NAD+ | - |
Agrobacterium tumefaciens | |
NAD+ | - |
Brachyspira hyodysenteriae | |
NAD+ | - |
Deinococcus radiodurans | |
NAD+ | - |
Deinococcus deserti | |
NAD+ | - |
Deinococcus gobiensis | |
NAD+ | - |
Delftia acidovorans |
General Information | Comment | Organism |
---|---|---|
physiological function | in bacteria NAD-dependent RNA 2'-phosphotransferase KptA might be an RNA processing enzyme able to repair the RNA damaged by toxic endoribonucleases | Catenulispora acidiphila |
physiological function | in yeast the NAD-dependent RNA 2'-phosphotransferase KptA is known to participate in tRNA splicing by removing the splice junction 2'-phosphate from ligated tRNA | Saccharomyces cerevisiae |
physiological function | the genomic organization of gene kptA suggests that KptA activity is strictly coordinated with the recycling to NAD of its reaction products | Flavobacterium johnsoniae |