Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Human alphaherpesvirus 1 |
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate | IC50: 0.028 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate | IC50: 0.03 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate | IC50: 0.0046 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate | IC50: 0.281 mM | Human alphaherpesvirus 1 | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate | IC50: 0.019 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate | IC50: 0.011 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate | IC50: 0.42 mM | Human alphaherpesvirus 1 | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate | IC50: 0.04 mM | Homo sapiens | |
(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | IC50: 0.265 mM | Homo sapiens | |
(4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | IC50: 0.371 mM | Homo sapiens | |
(4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.18 mM | Homo sapiens | |
1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.18 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.057 mM | Homo sapiens | |
1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.057 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.022 mM | Homo sapiens | |
1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.0035 mM; IC50: above 0.5 mM | Homo sapiens | |
1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.0035 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine | IC50: 0.01 mM | Homo sapiens | |
1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.173 mM | Homo sapiens | |
1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.224 mM | Human alphaherpesvirus 1 | |
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.017 mM | Homo sapiens | |
1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.013 mM | Human alphaherpesvirus 1 | |
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.0036 mM | Homo sapiens | |
1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | IC50: 0.0012 mM | Human alphaherpesvirus 1 | |
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | IC50: 0.023 mM | Homo sapiens | |
2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | IC50: 0.198 mM | Human alphaherpesvirus 1 | |
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | IC50: 0.0041 mM | Homo sapiens | |
2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | IC50: 0.119 mM | Human alphaherpesvirus 1 | |
3'-O-ethyl-2'-deoxyuridine | - |
Homo sapiens | |
3'-O-methyl-2'-deoxyuridine | - |
Homo sapiens | |
3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine | inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM | Homo sapiens | |
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide | IC50: 0.44 mM | Homo sapiens | |
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide | IC50: 0.175 mM | Human alphaherpesvirus 1 | |
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide | IC50: 0.194 mM | Homo sapiens | |
4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide | IC50: 0.191 mM | Human alphaherpesvirus 1 | |
5'-O-(4,4'-dimethoxytrityl)thymidine | IC50: 0.468 mM | Homo sapiens | |
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: 0.0013 mM; IC50: 0.1 mM | Homo sapiens | |
5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
5-(E)-(2-bromovinyl)uridine | inhibits phosphorylation of 2'-deoxythymidine | Homo sapiens | |
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: 0.02 mM | Homo sapiens | |
5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: 0.0046 mM | Homo sapiens | |
5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | IC50: 0.048 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.025 mM | Homo sapiens | |
5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.003 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.491 mM | Homo sapiens | |
5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.491 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.0023 mM; IC50: above 0.5 mM | Homo sapiens | |
5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.0023 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine | IC50: 0.484 mM | Homo sapiens | |
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.0015 mM; IC50: above 0.1 mM | Homo sapiens | |
5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.045 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.404 mM | Homo sapiens | |
5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.0031 mM | Human alphaherpesvirus 1 | |
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.0033 mM | Homo sapiens | |
5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione | IC50: 0.01 mM | Human alphaherpesvirus 1 | |
5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine | competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mm | Homo sapiens | |
5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine | IC50: 0.006 mM | Homo sapiens | |
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide | IC50: 0.019 mM | Homo sapiens | |
6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide | IC50: 0.0034 mM | Human alphaherpesvirus 1 | |
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine | IC50: above 0.5 mM | Homo sapiens | |
9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.46 mM | Homo sapiens | |
N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.353 mM | Homo sapiens | |
N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.318 mM | Homo sapiens | |
N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.268 mM | Homo sapiens | |
N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.238 mM | Homo sapiens | |
N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.038 mM | Homo sapiens | |
N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.043 mM | Human alphaherpesvirus 1 | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide | IC50: 0.027 mM | Homo sapiens | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide | IC50: 0.115 mM | Human alphaherpesvirus 1 | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide | IC50: 0.028 mM | Homo sapiens | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide | IC50: 0.072 mM | Human alphaherpesvirus 1 | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide | IC50: 0.033 mM | Homo sapiens | |
N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide | IC50: 0.131 mM | Human alphaherpesvirus 1 | |
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.287 mM | Homo sapiens | |
N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: above 0.5 mM | Human alphaherpesvirus 1 | |
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.208 mM | Homo sapiens | |
N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | IC50: 0.495 mM | Human alphaherpesvirus 1 | |
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.075 mM | Homo sapiens | |
N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | IC50: 0.275 mM | Human alphaherpesvirus 1 | |
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine | IC50: above 0.5 mM | Homo sapiens | |
N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine | IC50: above 0.5 mM | Human alphaherpesvirus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00142 | - |
- |
Homo sapiens | P04183 | - |
- |
Human alphaherpesvirus 1 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-(beta-D-arabinofuranosyl)thymine | - |
Human alphaherpesvirus 1 | ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate | - |
? | |
ATP + 1-(beta-D-arabinofuranosyl)thymine | - |
Homo sapiens | ADP + 1-(beta-D-arabinofuranosyl)thymine 5'-phosphate | - |
? | |
ATP + 2'-deoxythymidine | - |
Human alphaherpesvirus 1 | ADP + 2'-deoxythymidine 5'-phosphate | - |
? | |
ATP + 2'-deoxythymidine | - |
Homo sapiens | ADP + 2'-deoxythymidine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Mt-TK | - |
Homo sapiens |
thymidine kinase 2, mitochondrial | - |
Homo sapiens |
TK-2 | - |
Homo sapiens |
TK1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
IC50: 0.0012 mM | Human alphaherpesvirus 1 | 1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.0012 | - |
competitive with respect to 2'-deoxythymidine, IC50: 0.0012 mM | Homo sapiens | 5-[(E)-2-bromoethenyl]-2'-O-decanoyluridine | |
0.0013 | - |
IC50: 0.0013 mM | Homo sapiens | 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.0015 | - |
IC50: 0.0015 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.0023 | - |
IC50: 0.0023 mM | Human alphaherpesvirus 1 | 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.0023 | - |
IC50: 0.0023 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.003 | - |
IC50: 0.003 mM | Human alphaherpesvirus 1 | 5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.0031 | - |
IC50: 0.0031 mM | Human alphaherpesvirus 1 | 5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.0033 | - |
IC50: 0.0033 mM | Homo sapiens | 5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione | |
0.0034 | - |
IC50: 0.0034 mM | Human alphaherpesvirus 1 | 6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide | |
0.0035 | - |
IC50: 0.0035 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.0035 | - |
IC50: 0.0035 mM | Homo sapiens | 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.0036 | - |
IC50: 0.0036 mM | Homo sapiens | 1-[3-hydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.0041 | - |
IC50: 0.0041 mM | Homo sapiens | 2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | |
0.0046 | - |
IC50: 0.0046 mM | Homo sapiens | 5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.0046 | - |
IC50: 0.0046 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate | |
0.0046 | - |
inhibits phosphorylation of 2'-deoxythymidine, IC50: 0.0046 mM | Homo sapiens | 3'-spiro-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-5-methyluridine | |
0.006 | - |
IC50: 0.006 mM | Homo sapiens | 5-[(E)-2-bromoethenyl]-2'-O-octanoyluridine | |
0.01 | - |
IC50: 0.01 mM | Human alphaherpesvirus 1 | 5-methyl-1-[4-(trityloxy)butyl]pyrimidine-2,4(1H,3H)-dione | |
0.01 | - |
IC50: 0.01 mM | Homo sapiens | 1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine | |
0.011 | - |
IC50: 0.011 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate | |
0.013 | - |
IC50: 0.013 mM | Human alphaherpesvirus 1 | 1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.017 | - |
IC50: 0.017 mM | Homo sapiens | 1-[2,3-dihydroxy-4-(trityloxy)butyl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.019 | - |
IC50: 0.019 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate | |
0.019 | - |
IC50: 0.019 mM | Homo sapiens | 6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylhexanamide | |
0.02 | - |
IC50: 0.02 mM | Homo sapiens | 5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.022 | - |
IC50: 0.022 mM | Homo sapiens | 1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.023 | - |
IC50: 0.023 mM | Homo sapiens | 2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | |
0.025 | - |
IC50: 0.025 mM | Homo sapiens | 5-methyl-1-[(2E)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.027 | - |
IC50: 0.027 mM | Homo sapiens | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide | |
0.028 | - |
IC50: 0.028 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate | |
0.028 | - |
IC50: 0.028 mM | Homo sapiens | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide | |
0.03 | - |
IC50: 0.03 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate | |
0.033 | - |
IC50: 0.033 mM | Homo sapiens | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide | |
0.038 | - |
IC50: 0.038 mM | Homo sapiens | N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.04 | - |
IC50: 0.04 mM | Homo sapiens | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate | |
0.043 | - |
IC50: 0.043 mM | Human alphaherpesvirus 1 | N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.045 | - |
IC50: 0.045 mM | Human alphaherpesvirus 1 | 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.048 | - |
IC50: 0.048 mM | Human alphaherpesvirus 1 | 5-iodo-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.057 | - |
IC50: 0.057 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.057 | - |
IC50: 0.057 mM | Homo sapiens | 1-[(2Z)-4-(benzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.072 | - |
IC50: 0.072 mM | Human alphaherpesvirus 1 | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-3-(trifluoromethyl)benzamide | |
0.075 | - |
IC50: 0.075 mM | Homo sapiens | N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.1 | - |
IC50: 0.1 mM | Homo sapiens | 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.1 | - |
IC50: above 0.1 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.115 | - |
IC50: 0.115 mM | Human alphaherpesvirus 1 | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-2,2-diphenylacetamide | |
0.119 | - |
IC50: 0.119 mM | Human alphaherpesvirus 1 | 2-biphenyl-4-yl-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | |
0.131 | - |
IC50: 0.131 mM | Human alphaherpesvirus 1 | N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]-9H-xanthene-9-carboxamide | |
0.173 | - |
IC50: 0.173 mM | Homo sapiens | 1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.175 | - |
IC50: 0.175 mM | Human alphaherpesvirus 1 | 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide | |
0.18 | - |
IC50: 0.18 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.18 | - |
IC50: 0.18 mM | Homo sapiens | 1-[(2Z)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.191 | - |
IC50: 0.191 mM | Human alphaherpesvirus 1 | 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide | |
0.194 | - |
IC50: 0.194 mM | Homo sapiens | 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-[2-oxo-2-(tritylamino)ethyl]butanamide | |
0.198 | - |
IC50: 0.198 mM | Human alphaherpesvirus 1 | 2-(4-chlorophenyl)-N-[(2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl]acetamide | |
0.208 | - |
IC50: 0.208 mM | Homo sapiens | N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.224 | - |
IC50: 0.224 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-hydroxybut-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.238 | - |
IC50: 0.238 mM | Homo sapiens | N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.265 | - |
IC50: 0.265 mM | Homo sapiens | (4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | |
0.268 | - |
IC50: 0.268 mM | Homo sapiens | N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.275 | - |
IC50: 0.275 mM | Human alphaherpesvirus 1 | N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.281 | - |
IC50: 0.281 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl diphenylacetate | |
0.287 | - |
IC50: 0.287 mM | Homo sapiens | N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.318 | - |
IC50: 0.318 mM | Homo sapiens | N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.353 | - |
IC50: 0.353 mM | Homo sapiens | N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.371 | - |
IC50: 0.371 mM | Homo sapiens | (4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | |
0.404 | - |
IC50: 0.404 mM | Homo sapiens | 5-methyl-1-[4-(trityloxy)but-2-yn-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.42 | - |
IC50: 0.42 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl heptanoate | |
0.44 | - |
IC50: 0.44 mM | Homo sapiens | 4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-tritylbutanamide | |
0.46 | - |
IC50: 0.46 mM | Homo sapiens | N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.468 | - |
IC50: 0.468 mM | Homo sapiens | 5'-O-(4,4'-dimethoxytrityl)thymidine | |
0.484 | - |
IC50: 0.484 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine | |
0.491 | - |
IC50: 0.491 mM | Human alphaherpesvirus 1 | 5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.491 | - |
IC50: 0.491 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(4-methylpiperazin-1-yl)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.495 | - |
IC50: 0.495 mM | Human alphaherpesvirus 1 | N-[cyano(phenyl)methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 5-(E)-(2-bromovinyl)-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.5 | - |
IC50: above 0.5 mM | Homo sapiens | 1-[(2Z)-4-(dibenzylamino)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.5 | - |
IC50: above 0.5 mM | Homo sapiens | 5-methyl-1-[(2Z)-4-(tritylamino)but-2-en-1-yl]pyrimidine-2,4(1H,3H)-dione | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine | |
0.5 | - |
IC50: above 0.5 mM | Homo sapiens | 9-[(2Z)-4-(trityloxy)but-2-en-1-yl]-guanine | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 5-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-cytosine | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine | |
0.5 | - |
IC50: above 0.5 mM | Homo sapiens | N3-methyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-thymine | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 5-ethyl-1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-uracil | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-(trityloxy)but-2-en-1-yl]-5,6-dihydrothymine | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl pivalate | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl 3,3-dimethylbutanoate | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl dodecanoate | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (2Z)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)but-2-en-1-yl benzoate | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | 1-[(2Z)-4-(benzyloxy)but-2-en-1-yl]-5-methylpyrimidine-2,4(1H,3H)-dione | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-(2-cyanoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-(diphenylmethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-(2-[[cyano(phenyl)methyl]amino]-2-oxoethyl)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-[2-[(diphenylmethyl)amino]-2-oxoethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)butanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-(cyanomethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | N-(2-cyanoethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hexanamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (4E)-N-[cyano(phenyl)methyl]-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide | |
0.5 | - |
IC50: above 0.5 mM | Human alphaherpesvirus 1 | (4E)-N-(diphenylmethyl)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)hex-4-enamide |