Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hydrogen peroxide | limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin, acts by direct oxidation of the receptor tyrosine kinase or indirectly by oxidation of protein tyrosine phosphatase | Homo sapiens | |
Insulin | induces receptor activation by autophosphorylation | Homo sapiens | |
thiol/disulfide | regulation of insulin receptor tyrosine kinase activity by shifts in the redox status | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydrogen peroxide | limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
hydrogen peroxide | insulin-induced ROS production, limited exposure enhances insulin-induced autophosphorylation of the insulin receptor, while prolonged exposure impairs the action of insulin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activation by autophosphorylation of insulin receptor via its tyrosine kinase activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | insulin receptor tyrosine kinase is activated via autophosphorylation, the receptor plays a role in signalling which is redox autoregulated by insulin-induced reactive oxygen species involving an autoregulatory loop, redundant mechanisms, overview, physiologic implications for diabetes and hyperglycemia | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
insulin receptor kinase | - |
Homo sapiens |
insulin receptor tyrosine kinase | - |
Homo sapiens |
IRK | - |
Homo sapiens |