Application | Comment | Organism |
---|---|---|
drug development | new substance class (4-(indole-3-yl)quinazolines) for the treatment of EGFR-dependent tumors, showing strong fluorescences. No connection between cytotoxicity and EGFR-TK inhibition | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(5-bromoindole-3-yl)-6,7-dimethoxyquinazoline | relatively potent inhibitor of EGFR-TK activity | Homo sapiens | |
4-(5-chloro-6-fluoro-indole-3-yl)-6,7-di-(2-methoxyethoxy)quinazoline | relatively potent inhibitor of EGFR-TK activity | Homo sapiens | |
4-(5-chloro-6-fluoroindole-3-yl)-6,7-dimethoxyquinazoline | relatively potent inhibitor of EGFR-TK activity, is a dual EGFR-TK and HER-2-TK inhibitor | Homo sapiens | |
4-(5-chloro-6-fluoroindole-3-yl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazoline | relatively potent inhibitor of EGFR-TK activity, is a dual EGFR-TK and HER-2-TK inhibitor | Homo sapiens | |
4-(6-fluoro-5-methylindole-3-yl)-6,7-dimethoxyquinazoline | relatively potent inhibitor of EGFR-TK activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-498 cell | - |
Homo sapiens | - |
ACHN cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
IGROV-1 cell | - |
Homo sapiens | - |
additional information | EKVX cell, HOP-92 cell, NCI-H322M cell, TK-10 cell and SNB-75 cell | Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(Glu:Tyr) + ATP | - |
Homo sapiens | ADP + poly(Glu:Tyr) phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EGFR tyrosine kinase | - |
Homo sapiens |
EGFR-TK | - |
Homo sapiens |
epidermal growth factor receptor tyrosine kinase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000131 | - |
- |
Homo sapiens | 4-(5-bromoindole-3-yl)-6,7-dimethoxyquinazoline | |
0.000209 | - |
- |
Homo sapiens | 4-(5-chloro-6-fluoroindole-3-yl)-6,7-dimethoxyquinazoline | |
0.000333 | - |
- |
Homo sapiens | 4-(5-chloro-6-fluoroindole-3-yl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazoline | |
0.000472 | - |
- |
Homo sapiens | 4-(5-chloro-6-fluoro-indole-3-yl)-6,7-di-(2-methoxyethoxy)quinazoline | |
0.000533 | - |
- |
Homo sapiens | 4-(6-fluoro-5-methylindole-3-yl)-6,7-dimethoxyquinazoline |