Activating Compound | Comment | Organism | Structure |
---|---|---|---|
macrophage stimulating protein | MSP, its only known ligand, both MSP-dependent and MSP-independent signaling by RON. RON exhibits MSP-independent tyrosine phosphorylation in MCF-10A cells. RON exhibits increased phosphorylation on Y1238/1239 and on the Y1360 docking site in the presence of exogenously added MSP. Similar levels of RON expression in NIH-3T3 cells do not lead to tyrosine phosphorylation of RON in the absence of ligand. MSP-independent tyrosine phosphorylation of RON also in HeLa cells | Homo sapiens | |
additional information | tyrosine phosphorylation of RON depends on the activity of Src family kinases | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | RON has two alternative modes of signaling that can contribute to oncogenic behavior in normal breast epithelial cells. RON-mediated proliferation requires MSP. RON-mediated cell spreading or RON-mediated evasion of cell death are MSP independent | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
MCF-10A cells transduced with a retrovirus expressing wild-type human RON | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K1114M | kinase dead mutant of RON, which does not exhibit any tyrosine phosphorylation in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | PP2, completely abrogates RON-mediated cell spreading both in the absence and presence of MSP | Homo sapiens | |
LY294002 | PI3K/AKT inhibitor, has no effects on RON-mediated cell spreading either with or without MSP, but completely abrogates the cell survival properties of RON and reduces MSP-induced Transwell migration by 60-80% | Homo sapiens | |
U0126 | MEK/ERK inhibitor, has no effects on RON-mediated cell spreading either with or without MSP, but completely abrogates the cell survival properties of RON and reduces MSP-induced Transwell migration by 60-80% | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
MCF-10A cell | endogenous levels of RON are low | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
recepteur d'origine nantais | - |
Homo sapiens |
Ron | - |
Homo sapiens |
RON receptor tyrosine kinase | - |
Homo sapiens |