Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Escherichia coli | |
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Saccharomyces cerevisiae | |
Mg2+ | required | Geobacillus stearothermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | Escherichia coli | - |
2 ADP | - |
r | |
ATP + AMP | Homo sapiens | - |
2 ADP | - |
r | |
ATP + AMP | Saccharomyces cerevisiae | - |
2 ADP | - |
r | |
ATP + AMP | Geobacillus stearothermophilus | - |
2 ADP | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Geobacillus stearothermophilus | - |
- |
- |
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + AMP = 2 ADP | induced-fit and change between open and closed conformation, random Bi-Bi reaction mechanism, the conformational change of the ADK enzyme very much follows two parallel stepwise pathways as a functional requirement for the double substrate catalysis | Escherichia coli | |
ATP + AMP = 2 ADP | induced-fit and change between open and closed conformation, random Bi-Bi reaction mechanism, the conformational change of the ADK enzyme very much follows two parallel stepwise pathways as a functional requirement for the double substrate catalysis | Homo sapiens | |
ATP + AMP = 2 ADP | induced-fit and change between open and closed conformation, random Bi-Bi reaction mechanism, the conformational change of the ADK enzyme very much follows two parallel stepwise pathways as a functional requirement for the double substrate catalysis | Saccharomyces cerevisiae | |
ATP + AMP = 2 ADP | induced-fit and change between open and closed conformation, random Bi-Bi reaction mechanism, the conformational change of the ADK enzyme very much follows two parallel stepwise pathways as a functional requirement for the double substrate catalysis | Geobacillus stearothermophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | - |
Escherichia coli | 2 ADP | - |
r | |
ATP + AMP | - |
Homo sapiens | 2 ADP | - |
r | |
ATP + AMP | - |
Saccharomyces cerevisiae | 2 ADP | - |
r | |
ATP + AMP | - |
Geobacillus stearothermophilus | 2 ADP | - |
r | |
ATP + AMP | substrate ligand-binding modeling, detailed overview | Escherichia coli | 2 ADP | - |
r | |
ATP + AMP | substrate ligand-binding modeling, detailed overview | Homo sapiens | 2 ADP | - |
r | |
ATP + AMP | substrate ligand-binding modeling, detailed overview | Saccharomyces cerevisiae | 2 ADP | - |
r | |
ATP + AMP | substrate ligand-binding modeling, detailed overview | Geobacillus stearothermophilus | 2 ADP | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ADK | - |
Escherichia coli |
ADK | - |
Homo sapiens |
ADK | - |
Saccharomyces cerevisiae |
ADK | - |
Geobacillus stearothermophilus |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme adenylate kinase dynamics-function relationships, modelling using crystal structure PDB ID 1ANK, comparisons of different enzyme structures and substrate binding structures, detailed overview | Escherichia coli |
additional information | enzyme adenylate kinase dynamics-function relationships, modelling using crystal structure PDB ID 1DVR, comparisons of different enzyme structures and substrate binding structures, detailed overview | Saccharomyces cerevisiae |
additional information | enzyme adenylate kinase dynamics-function relationships, modelling using crystal structure PDB ID 1ZIN, comparisons of different enzyme structures and substrate binding structures, detailed overview | Geobacillus stearothermophilus |
additional information | enzyme adenylate kinase dynamics-function relationships, modelling using crystal structure PDB ID 2BBW, comparisons of different enzyme structures and substrate binding structures, detailed overview | Homo sapiens |