Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-(3-methoxypropyl)-8-(1-methyl-1H-pyrazol-4-yl)-2,5-dihydro-1H-indeno[1,2-d]pyrimidine | inhibits HIV-1 reverse transcriptase in a primer extension assay but has no measurable activity against human DNA polymerase gamma at 0.01 mM. It potently inhibits HIV-1 replication in vitro with 1.5 nM 50% effective concentration. The antiviral potency is unaffected by the presence of nonnucleotide RT inhibitor mutations L100I, K103N/Y181C, V106A, or Y188L. Viruses encoding K65R are hypersusceptible to inhibition by the compound, and it retains full activity against viruses encoding M184V. A recombinant virus encoding the RT W153L is highly resistant | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000026 | - |
pH 7.8, 37°C | Human immunodeficiency virus 1 | 4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-(3-methoxypropyl)-8-(1-methyl-1H-pyrazol-4-yl)-2,5-dihydro-1H-indeno[1,2-d]pyrimidine |