Literature summary for 2.7.7.49 extracted from

Kang, D.; Zhang, H.; Wang, Z.; Zhao, T.; Ginex, T.; Luque, F.J.; Yang, Y.; Wu, G.; Feng, D.; Wei, F.; Zhang, J.; De Clercq, E.; Pannecouque, C.; Chen, C.H.; Lee, K.H.; Murugan, N.A.; Steitz, T.A.; Zhan, P.; Liu, X.
Identification of dihydrofuro[3,4-d]pyrimidine derivatives as novel HIV-1 non-nucleoside reverse transcriptase inhibitors with promising antiviral activities and desirable physicochemical properties (2019), J. Med. Chem., 62, 1484-1501 .

Inhibitors

Inhibitors	Comment	Organism
3,5-dimethyl-4-[[2-([(3R)-1-[(pyridin-4-yl)methyl]pyrrolidin-3-yl]amino)thieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	exceptionally potent against a wide range of HIV-1 strains carrying single NNRTI-resistant mutations	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([(3S)-1-[(pyridin-4-yl)methyl]pyrrolidin-3-yl]amino)thieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]-1,2,3,4-tetrahydropyridin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]azepan-4-yl]amino)thieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]azetidin-3-yl]amino)thieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,6,7,8-tetrahydroquinazolin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3,5-dimethyl-4-[[2-([8-[(pyridin-4-yl)methyl]-8-azabicyclo[3.2.1]octan-3-yl]amino)thieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile	-	Human immunodeficiency virus 1
3-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azetidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azepan-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
3-[[(3R)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzamide	exceptionally potent against a wide range of HIV-1 strains carrying single NNRTI-resistant mutations. Favorable pharmacokinetic properties with an oral bioavailability of 30.96% and a half-life of 11.1 h.Ppromising anti-HIV-1 drug candidate with potent antiviral activities and desirable drug-like properties.	Human immunodeficiency virus 1
3-[[(3S)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzamide	-	Human immunodeficiency virus 1
4-((4-((4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro-[3,4-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]-1,2,3,4-tetrahydropyridin-4-yl)amino]-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]azepan-4-yl)amino]thieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]azetidin-3-yl)amino]thieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,6,7,8-tetrahydroquinazolin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-([2-[(8-[[4-(methanesulfonyl)phenyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl)amino]thieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-[(2-[[(3R)-1-[[4-(methanesulfonyl)phenyl]methyl]pyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-[(2-[[(3S)-1-[[4-(methanesulfonyl)phenyl]methyl]pyrrolidin-3-yl]amino]thieno[3,2-d]pyrimidin-4-yl)oxy]-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
4-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]-8-azabicyclo[3.2.1]octan-8-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azetidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azetidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azepan-1-yl)methyl]benzamide	-	Human immunodeficiency virus 1
4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]azepan-1-yl)methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[[(3R)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzamide	-	Human immunodeficiency virus 1
4-[[(3R)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[[(3S)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzamide	-	Human immunodeficiency virus 1
4-[[(3S)-3-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]pyrrolidin-1-yl]methyl]benzene-1-sulfonamide	-	Human immunodeficiency virus 1
4-[[2-([1-[(4-aminophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]-3,5-dimethylbenzonitrile	-	Human immunodeficiency virus 1
N-[4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]phenyl]methanesulfonamide	-	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Synonyms

Synonyms	Comment	Organism
reverse transcriptase	-	Human immunodeficiency virus 1

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000051	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000051	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000056	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile
0.000066	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000072	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-5,6,7,8-tetrahydroquinazolin-4-yl]oxy]benzonitrile
0.000073	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000074	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile
0.000074	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide
0.000077	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile
0.000084	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide
0.000091	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000091	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]-1,2,3,4-tetrahydropyridin-4-yl)amino]-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile
0.000091	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide
0.000092	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrofuro[3,4-d]pyrimidin-4-yl]oxy]benzonitrile
0.000094	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl]oxy]benzonitrile
0.000094	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.0000989	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-5,6,7,8-tetrahydroquinazolin-4-yl]oxy)-3,5-dimethylbenzonitrile
0.000101	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,6,7,8-tetrahydroquinazolin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.000109	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide
0.000112	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(pyridin-4-yl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile
0.000115	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[[2-([1-[(4-aminophenyl)methyl]piperidin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]-3,5-dimethylbenzonitrile
0.000129	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]-1,2,3,4-tetrahydropyridin-4-yl]amino)-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]oxy]benzonitrile
0.00013	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile
0.00014	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	N-[4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]phenyl]methanesulfonamide
0.000157	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-([2-[(1-[[4-(methanesulfonyl)phenyl]methyl]piperidin-4-yl)amino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy)-3,5-dimethylbenzonitrile
0.000175	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl]oxy]benzonitrile
0.000241	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3,5-dimethyl-4-[[2-([1-[(4-nitrophenyl)methyl]piperidin-4-yl]amino)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]oxy]benzonitrile
0.000241	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	3-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzamide
0.00041	-	inhibition against wild-type enzyme, pH and temperature not specified in the publication	Human immunodeficiency virus 1	4-[(4-[[4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl]amino]piperidin-1-yl)methyl]benzene-1-sulfonamide

General Information

General Information	Comment	Organism
drug target	4-((4-((4-(4-cyano-2,6-dimethylphenoxy)-5,7-dihydrofuro-[3,4-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide is a promising anti-HIV-1 drug candidate with potent antiviral activities and desirable drug-like properties	Human immunodeficiency virus 1