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Literature summary for 2.7.7.49 extracted from

  • Jackson, L.N.; Chim, N.; Shi, C.; Chaput, J.C.
    Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase (2019), Nucleic Acids Res., 47, 6973-6983 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.49

Cloned(Commentary)

Cloned (Comment) Organism
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 Geobacillus stearothermophilus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of natural Bst DNA polymerase that capture the post-translocated product of DNA synthesis on templates composed entirely of 2'-deoxy-2'-fluoro-beta-D-arabino nucleic acid and alpha-L-threo-furanosyl nucleic acid Geobacillus stearothermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn Geobacillus stearothermophilus
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 diphosphate + DNAn+1
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 ?

Organism

Organism UniProt Comment Textmining
Geobacillus stearothermophilus E1C9K5 cf. EC 2.7.7.7; synthetic construct
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Purification (Commentary)

Purification (Comment) Organism
-
 Geobacillus stearothermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn
-
 Geobacillus stearothermophilus diphosphate + DNAn+1
-
 ?
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn the enzyme exhibits an innate ability to reverse transcribe RNA and other synthetic congeners (XNAs) into DNA. Analysis of the active site of the enzyme reveals the importance of structural plasticity as a possible mechanism for XNA-dependent DNA synthesis Geobacillus stearothermophilus diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
Bst DNA polymerase
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 Geobacillus stearothermophilus
XNA reverse transcriptase
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 Geobacillus stearothermophilus