Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CK2 | is associated with Pol I, the initiation-competent subclass of Pol I, CK2 phosphorylates a number of proteins involved in Pol I transcription and pre-rRNA processing, including UBF, TIF-IA, SL1/TIF-IB, topoisomerase IIa, nucleolin, and nucleophosmin, overview | Mus musculus | |
CK2 | is associated with Pol I, the initiation-competent subclass of Pol I, CK2 phosphorylates a number of proteins involved in Pol I transcription and pre-rRNA processing, including UBF, TIF-IA, SL1/TIF-IB, topoisomerase IIa, nucleolin, and nucleophosmin, overview | Homo sapiens | |
additional information | The activity of basal Pol I factors is regulated by posttranslational modifications | Mus musculus | |
additional information | The activity of basal Pol I factors is regulated by posttranslational modifications | Homo sapiens | |
PAF53 | a 53-kDa protein that is associated with Pol I, recruitment of Pol I to the pre-initiation complex requires the interaction of UBF with SL1/TIF-IB and with PAF53 | Mus musculus | |
PAF53 | a 53-kDa protein that is associated with Pol I, recruitment of Pol I to the pre-initiation complex requires the interaction of UBF with SL1/TIF-IB and with PAF53 | Homo sapiens | |
TAFI protein | performs important tasks in transcription complex assembly, mediating specific interactions between the rDNA promoter and Pol I, thereby recruiting Pol I, together with a collection of Pol I-associated factors, to rDNA | Mus musculus | |
TAFI protein | performs important tasks in transcription complex assembly, mediating specific interactions between the rDNA promoter and Pol I, thereby recruiting Pol I, together with a collection of Pol I-associated factors, to rDNA | Homo sapiens | |
TIF-IB/SL 1 | Pol I promoter specificity is conferred by TIF-IB/SL1, a protein complex containing the TATA binding protein and five TATA binding protein-associated factors, including TAFI110/95, TAFI68, TAFI48, TAFI35, and TAFI12 | Mus musculus | |
TIF-IB/SL 1 | Pol I promoter specificity is conferred by TIF-IB/SL1, a protein complex containing the TATA binding protein and five TATA binding protein-associated factors, including TAFI110/95, TAFI68, TAFI48, TAFI35, and TAFI12 | Homo sapiens | |
upstream binding factor | UBF, activates rRNA gene transcription by several means, for example, by recruiting Pol I to the rDNA promoter, by stabilizing binding of TIF-IB/SL1, and by displacing nonspecific DNA binding proteins such as histone H1. And UBF has additional roles in regulation of Pol I promoter escape and transcription elongation | Mus musculus | |
upstream binding factor | UBF, activates rRNA gene transcription by several means, for example, by recruiting Pol I to the rDNA promoter, by stabilizing binding of TIF-IB/SL1, and by displacing nonspecific DNA binding proteins such as histone H1. And UBF has additional roles in regulation of Pol I promoter escape and transcription elongation | Homo sapiens |
Application | Comment | Organism |
---|---|---|
drug development | development of drugs that target the Pol I transcription machinery at different points for use in cancer therapies, overview | Mus musculus |
drug development | development of drugs that target the Pol I transcription machinery at different points for use in cancer therapies, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | oncogenes and tumor suppressors control Pol I transcription, overview. Development of drugs that target the Pol I transcription machinery at different points, overveiw | Homo sapiens | |
additional information | oncogenes and tumor suppressors control Pol I transcription, overview. Development of drugs that target the Pol I transcription machinery at different points, overveiw | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications | ? | - |
? | |
additional information | Homo sapiens | two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications | ? | - |
? | |
nucleoside triphosphate + RNAn | Mus musculus | template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | Homo sapiens | template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | The activity of basal Pol I factors is regulated by posttranslational modifications, overview, e.g. acetylation is a posttranslational modification that regulates the activity of basal Pol I transcription factors, including UBF and SL1/TIF-IB | Mus musculus |
additional information | The activity of basal Pol I factors is regulated by posttranslational modifications, overview, e.g. acetylation is a posttranslational modification that regulates the activity of basal Pol I transcription factors, including UBF and SL1/TIF-IB | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Mus musculus | - |
carcinoma cell | - |
Homo sapiens | - |
fibroblast | - |
Mus musculus | - |
fibroblast | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
additional information | aside from growth-dependent regulation, Pol I transcription also oscillates during cell cycle progression. Transcription is maximal during S- and G2-phase, subsides during mitosis, and then slowly recovers during G1-phase | Mus musculus | - |
additional information | aside from growth-dependent regulation, Pol I transcription also oscillates during cell cycle progression. Transcription is maximal during S- and G2-phase, subsides during mitosis, and then slowly recovers during G1-phase | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications | Mus musculus | ? | - |
? | |
additional information | two distinct forms, Pol Ialpha and Pol Ibeta. Both forms are catalytically active, but only Pol Ibeta can assemble into productive transcription initiation complexes. Regulation of Pol I transcription during cell cycle progression involving cytokines, and structural organization of mammalian rDNA repeats and the basal factors required for transcription initiation, overview. The activity of basal Pol I factors is regulated by posttranslational modifications | Homo sapiens | ? | - |
? | |
nucleoside triphosphate + RNAn | template is DNA | Mus musculus | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | template is DNA | Homo sapiens | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview | Mus musculus | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | template is DNA, epigenetic control of rDNA transcription, regulation system of RNA polymerase, detailed overview | Homo sapiens | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pol I | - |
Mus musculus |
Pol I | - |
Homo sapiens |
RNA polymerase I | - |
Mus musculus |
RNA polymerase I | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | mitotic silencing of Pol I transcription is caused by Cdk1/cyclin B-dependent phosphorylation of a single threonine residue Thr852 at TAFI110 that impairs the interaction of SL1/TIF-IB with UBF | down |
Homo sapiens | mitotic silencing of Pol I transcription is caused by Cdk1/cyclin B-dependent phosphorylation of a single threonine residue Thr852 at TAFI110 that impairs the interaction of SL1/TIF-IB with UBF | down |
Mus musculus | at the end of mitosis, Cdc14B, a phosphatase that is sequestered in an inactive state in the nucleolus during interphase and is released from rDNA during mitosis, dephosphorylates Thr852, thereby activating SL1 and relieving mitotic repression of Pol I transcription | up |
Homo sapiens | at the end of mitosis, Cdc14B, a phosphatase that is sequestered in an inactive state in the nucleolus during interphase and is released from rDNA during mitosis, dephosphorylates Thr852, thereby activating SL1 and relieving mitotic repression of Pol I transcription | up |
General Information | Comment | Organism |
---|---|---|
physiological function | detailed overview | Mus musculus |
physiological function | detailed overview | Homo sapiens |