Application | Comment | Organism |
---|---|---|
drug development | the enzyme is of interest as a target for antibiotic development | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AlCl3 | decreases enzyme substrate binding and turnover | Escherichia coli | |
Sodium fluoride | inhibition through the formation of a MgF3- complex within the enzyme active site | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + H2O | Escherichia coli | - |
AMP + phosphoenolpyruvate + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P23538 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate | phosphoenolpyruvate synthase catalyzes the conversion of pyruvate to phosphoenolpyruvate (PEP) using a two-step mechanism invoking a phosphorylated-His intermediate | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate + H2O | - |
Escherichia coli | AMP + phosphoenolpyruvate + phosphate | - |
ir | |
ATP + pyruvate + H2O | phospho-transfer mechanism, overview | Escherichia coli | AMP + phosphoenolpyruvate + phosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
PEPS | - |
Escherichia coli |
phosphoenolpyruvate synthase | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
metabolism | formation of phosphoenolpyruvate is an initial step in gluconeogenesis | Escherichia coli |
physiological function | the enzyme is essential for growth of Escherichia coli on 3-carbon sources such as pyruvate. The production of phosphoenolpyruvate synthase has also been linked to bacterial virulence and antibiotic resistance | Escherichia coli |