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Literature summary for 2.8.1.1 extracted from
- Inhibition of rat liver rhodanese by di-, tricarboxylic, and alpha-keto acids (1975), J. Biochem., 78, 825-834.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | incubation of mitochondria with 2-oxoglutarate causes a significant decrease in activity | Rattus norvegicus |  |
| anions | inhibited by most anions at rather high concentration, the most active inhibitors are aromatic anions, incubation of mitochondria with sulfate and 2-oxoglutarate causes a significant decrease in activity | Rattus norvegicus | |
| citrate | - |
Rattus norvegicus | |
| DL-isocitrate | - |
Rattus norvegicus | |
| fumarate | - |
Rattus norvegicus | |
| malate | - |
Rattus norvegicus | |
| oxaloacetate | - |
Rattus norvegicus | |
| pyruvate | - |
Rattus norvegicus | |
| SO42- | incubation of mitochondria with sulfate causes a significant decrease in activity | Rattus norvegicus | |
| succinate | - |
Rattus norvegicus | |
| sulfite | - |
Rattus norvegicus | |
| thiocyanate | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiosulfate + cyanide | Rattus norvegicus | - |
sulfite + thiocyanate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| thiosulfate + cyanide = sulfite + thiocyanate + H+ | double displacement mechanism | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 600 | - |
main fraction of Sephadex G-200 gel chromatography | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiosulfate + cyanide | - |
Rattus norvegicus | sulfite + thiocyanate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | purification yields two active fractions, of 17500 Da and 12600 Da by gel filtration | Rattus norvegicus |
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Release 2023.1 (January 2023)
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