Literature summary for 2.8.1.2 extracted from

Nagahara, N.; Koike, S.; Nirasawa, T.; Kimura, H.; Ogasawara, Y.
Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase (2018), Biochem. Biophys. Res. Commun., 496, 648-653 .

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Protein Variants

Protein Variants	Comment	Organism
C32S	mutant lacks formation of a disulfide bond with a protein and is not able to produce H2Sn	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P97532	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	after prolonged incubation of MST with thiosulfate, a trisulfide adduct becomes predominant at the sulfurated catalytic-site cysteine. When these adducts are reduced by Trx with reducing system H2S2 first appears, and then H2S and H2S3	Rattus norvegicus	?	-	-
thiosulfate + [3-mercaptopyruvate sulfurtransferase]-L-cysteine	-	Rattus norvegicus	sulfate + [3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine	-	?
[3-mercaptopyruvate sulfurtransferase]-S-sulfanyl-L-cysteine + reduced thioredoxin	-	Rattus norvegicus	hydrogen sulfide + [3-mercaptopyruvate sulfurtransferase]-L-cysteine + oxidized thioredoxin	-	?

Synonyms

Synonyms	Comment	Organism
MST	-	Rattus norvegicus

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Release 2023.1 (January 2023)