Cloned (Comment) | Organism |
---|---|
gene Sult2b1, recombinant overexpression of Ad-CMV-SULT2B1b via adenovirus vector in human wild-type and SULT2B1b-knockout GES-1 cells, quantitative RT-PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | SULT2B1b overexpression promotes gastric epithelial cell proliferation via the PI3K/AKT signaling pathway | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + (S)-cholest-5-ene-3beta,24S-diol | Mus musculus | - |
adenosine 3',5'-bisphosphate + (S)-cholest-5-ene-3beta,24S-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 24(R/S),25-epoxycholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 4beta-hydroxycholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + 4beta-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7-oxocholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + 7alpha-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + 7beta-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,25-diol | Mus musculus | - |
adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,25-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,27-diol | Mus musculus | - |
adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,27-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholesterol | Mus musculus | - |
adenosine 3',5'-bisphosphate + cholesterol 3-sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O35400 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric epithelium | abundant SULT2B1 expression in normal gastric epithelium | Mus musculus | - |
primary cell | - |
Mus musculus | - |
stomach | - |
Mus musculus | - |
stomach epithelium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + (S)-cholest-5-ene-3beta,24S-diol | - |
Mus musculus | adenosine 3',5'-bisphosphate + (S)-cholest-5-ene-3beta,24S-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 24(R/S),25-epoxycholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + ? | - |
? | |
3'-phosphoadenylyl sulfate + 4beta-hydroxycholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + 4beta-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7-oxocholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + 7alpha-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + 7beta-hydroxycholesterol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,25-diol | - |
Mus musculus | adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,25-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,27-diol | - |
Mus musculus | adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,27-diol 3-sulfate | - |
? | |
3'-phosphoadenylyl sulfate + cholesterol | - |
Mus musculus | adenosine 3',5'-bisphosphate + cholesterol 3-sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hydroxysteroid sulfotransferase 2B1 | - |
Mus musculus |
More | cf. EC 2.8.2.15 | Mus musculus |
SULT2B1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | gastric tumor incidence is higher in the SULT2B1-/- mice than in the wild-type mice. In gastric epithelial cells, adenovirus-mediated SULT2B1b overexpression reduces the levels of oxysterols, such as 24(R/S),25-epoxycholesterol (24(R/S),25-EC) and 27-hydroxycholesterol. This condition also increases PI3K/AKT signaling to promote gastric epithelial cell proliferation, epithelization, and epithelial development. SULT2B1 deletion or SULT2B1 knockdown suppresses PI3K/AKT signaling, epithelial cell epithelization, and wound healing and induced gastric epithelial cell malignant transition upon 3-MCA induction. SULT2B1 deletion inhibited PI3K/AKT signaling in response to growth factors, but SULT2B1 overexpression promotes this pathway | Mus musculus |
metabolism | SULT2B1b overexpression reduces the levels of oxysterols, such as 24(R/S),25-epoxycholesterol (24(R/S),25-EC) and 27-hydroxycholesterol. This condition also increases PI3K/AKT signaling to promote gastric epithelial cell proliferation, epithelization, and epithelial development. The PI3K/AKT signaling pathway plays essential roles in normal cellular functions, such as protein synthesis, growth control, and nutrition/energy balance. PI3K/AKT activation by growth factors can stimulate protein synthesis and cell growth | Mus musculus |
physiological function | hydroxysteroid sulfotransferase 2B1 (SULT2B1) affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent. The abundant SULT2B1 expression in normal gastric epithelium might maintain epithelial function via the PI3K/AKT signaling pathway and suppress gastric carcinogenesis induced by a carcinogenic agent. Enzyme SULT2B1 is involved in epithelial development | Mus musculus |