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Literature summary for 2.8.2.30 extracted from

  • Delos, M.; Foulquier, F.; Hellec, C.; Vicogne, D.; Fifre, A.; Carpentier, M.; Papy-Garcia, D.; Allain, F.; Denys, A.
    Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane (2018), Biochim. Biophys. Acta, 1862, 1644-1655 .
    View publication on PubMed
Search for more literature for 2.8.2.30

Cloned(Commentary)

Cloned (Comment) Organism
gene HS3ST3B, real-time RT-PCR expression analysis, recombinant expression in HeLa cells. Analysis of subcellular localization of the recombinant isozyme Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of a truncated mutant enzyme depleted of its catalytic domain. The mutant shows the same localization in the Golgi as the wild-type full-length enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
 adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y662
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
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macrophage primary macrophages. HS3ST3B is highly expressed in activated macrophages, highest after alternative stimulation (M2 polarization), while the enzyme is not detected in proinflammatory macrophages (M1) Homo sapiens
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monocyte the enzyme is not detected in primary monocytes Homo sapiens
-
additional information subcellular distribution of isozymes HS3ST2 and HS3ST3B is analysed by using overexpression systems in HeLa cells Homo sapiens
-
MRC5 SV-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?

Synonyms

Synonyms Comment Organism
heparan sulfate 3-O-sulfotransferase 3B
-
 Homo sapiens
HS3ST3B
-
 Homo sapiens

General Information

General Information Comment Organism
evolution both isozymes, HS3ST3B and HS3ST2 (EC 2.8.2.29), are differently expressed in monocytes and macrophages depending on the inflammatory environment Homo sapiens
metabolism heparan sulfate (HS) 3-O-sulfation can be catalysed by seven 3-sulfotransferases (HS3STs) in humans, but nevertheless it is the rarest modification in heparan sulfate (HS). Isozymes HS3ST2 (EC 2.8.2.29) and HS3ST3B exhibit the same activity in vitro. But they are differently expressed in macrophages depending on cell environment, which suggests that they may be involved in distinct cellular processes Homo sapiens