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Literature summary for 2.8.2.4 extracted from
- Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents (2006), Curr. Drug Metab., 7, 745-753.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional overexpression of SULT1E1 in Escherichia coli strain XL-1 blue cytosol | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetylsalicylate | binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex | Homo sapiens |  |
| Ibuprofen | - |
Homo sapiens | |
| indomethacin | - |
Homo sapiens | |
| meclofenamate | binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex | Homo sapiens | |
| naproxen | - |
Homo sapiens | |
| nimesulide | binds near enough to the substrate site to prevent catalysis but not affect dissociation of the substrate-enzyme complex | Homo sapiens | |
| piroxicam | - |
Homo sapiens | |
| salicylate | - |
Homo sapiens | |
| sulindac | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + beta-estradiol | Homo sapiens | - |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P49888 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, liver cytosol, 50 mM Tris-HCl, pH 7.8, 0.25 M sucrose, 0.5 mM EDTA, 0.1 mM DTT, and 0.02 mM BHT, no loss of activity during storage | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + beta-estradiol | - |
Homo sapiens | adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| estrogen sulfotransferase | - |
Homo sapiens |
| SULT1E1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0065 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | meclofenamate | |
| 0.038 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | sulindac | |
| 0.14 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | Ibuprofen | |
| 0.19 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | naproxen | |
| 0.23 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | nimesulide | |
| 0.27 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | piroxicam | |
| 0.91 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | salicylic acid | |
| 1.5 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | Acetylsalicylate | |
| 9.4 | - |
pH 6.5, 37°C, versus beta-estradiol | Homo sapiens | piroxicam | |
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