Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | in the Ni-F430 cofactor, which is bound to the active site and exists in two oxidation states | Methanothermobacter marburgensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate | Methanothermobacter marburgensis | i.e. CoM and CoB | CoM-S-S-CoB + methane | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanothermobacter marburgensis | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
methyl-CoM + CoB = CoM-S-S-CoB + methane | the first step of the mechanism is proposed to involve a nucleophilic attack of the NiI active state, MCRred1, on Me-SCoM to form a NiIII-methyl intermediate, spectroscopic analysis and structures, overview | Methanothermobacter marburgensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate | i.e. CoM and CoB | Methanothermobacter marburgensis | CoM-S-S-CoB + methane | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MCR | - |
Methanothermobacter marburgensis |
methyl-coenzyme M reductase | - |
Methanothermobacter marburgensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
F-430 | the Ni-F430 cofactor is bound to the active site and exists in two oxidation states | Methanothermobacter marburgensis |
General Information | Comment | Organism |
---|---|---|
metabolism | MCR catalyzes the terminal step in the formation of biological methane from methyl-coenzyme M and coenzyme B | Methanothermobacter marburgensis |