Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.1 extracted from

  • Zou, L.W.; Li, Y.G.; Wang, P.; Zhou, K.; Hou, J.; Jin, Q.; Hao, D.C.; Ge, G.B.; Yang, L.
    Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2 (2016), Eur. J. Med. Chem., 112, 280-288 .
    View publication on PubMed
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
18beta-11-deoxo-olean-12-en-30-oic acid
-
 Homo sapiens
18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
 Homo sapiens
18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
-
 Homo sapiens
18beta-11-oxo-olean-12-en-30-oic acid methyl ester
-
 Homo sapiens
18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
 Homo sapiens
18beta-3, 11-dioxo-olean-12-en-30-oic acid
-
 Homo sapiens
18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
-
 Homo sapiens
18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
-
 Homo sapiens
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
-
 Homo sapiens
18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
-
 Homo sapiens
18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
-
 Homo sapiens
18beta-glycyrrhetinic acid
-
 Homo sapiens
3-O-acetyl-11-oxo-olean-12-en-30-nitrile
-
 Homo sapiens
8beta-11-oxo-olean-12-en-30-amide
-
 Homo sapiens
8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
-
 Homo sapiens
bavachinin
-
 Homo sapiens
bis-4-nitrophenyl phosphate
-
 Homo sapiens
additional information design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview; design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterases, molecular docking, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00748
-
-
Homo sapiens P23141
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fluorescein diacetate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HCE1
-
 Homo sapiens
HCE2
-
 Homo sapiens
human carboxylesterase 1
-
 Homo sapiens
human carboxylesterase 2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.00014
-
 pH 7.4, 37°C Homo sapiens bis-4-nitrophenyl phosphate
0.00066
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
0.00342
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.00347
-
 pH 7.4, 37°C Homo sapiens bavachinin
0.00395
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.00399
-
 pH 7.4, 37°C Homo sapiens 18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.00431
-
 pH 7.4, 37°C Homo sapiens bavachinin
0.00561
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid methyl ester
0.0057
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
0.00611
-
 pH 7.4, 37°C Homo sapiens bis-4-nitrophenyl phosphate
0.00695
-
 pH 7.4, 37°C Homo sapiens 18beta-11-deoxo-olean-12-en-30-oic acid
0.00699
-
 pH 7.4, 37°C Homo sapiens 8beta-11-oxo-olean-12-en-30-amide
0.00736
-
 pH 7.4, 37°C Homo sapiens 8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
0.00913
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.01053
-
 pH 7.4, 37°C Homo sapiens 18beta-11-deoxo-olean-12-en-30-oic acid
0.01097
-
 pH 7.4, 37°C Homo sapiens 8beta-3-O-acetyl-11-oxo-olean-12-en-30-amide
0.01231
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid-(20-dimethylamino)ethyl ester
0.01421
-
 pH 7.4, 37°C Homo sapiens 8beta-11-oxo-olean-12-en-30-amide
0.02041
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-(beta-carboxypropionyl)-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.02075
-
 pH 7.4, 37°C Homo sapiens 18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
0.02097
-
 pH 7.4, 37°C Homo sapiens 18beta-glycyrrhetinic acid
0.02236
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid methyl ester
0.02361
-
 pH 7.4, 37°C Homo sapiens 18beta-3-oxo-11-deoxo-olean-12-en-30-oic acid
0.02509
-
 pH 7.4, 37°C Homo sapiens 18beta-11-deoxo-olean-12-en-30-oic acid ethyl ester
0.02626
-
 pH 7.4, 37°C Homo sapiens 18beta-11-oxo-olean-12-en-30-oic acid ethyl ester
0.04051
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
0.04986
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-acetyl-11-oxo-olean-12-en-30-oic acid
0.06926
-
 pH 7.4, 37°C Homo sapiens 18beta-glycyrrhetinic acid
0.1
-
 pH 7.4, 37°C Homo sapiens 18beta-3, 11-dioxo-olean-12-en-30-oic acid
0.1
-
 pH 7.4, 37°C Homo sapiens 18beta-3-O-(beta-carboxypropionyl)-11-oxo-olean-12-en-30-oic acid ethyl ester
0.1
-
 pH 7.4, 37°C Homo sapiens 3-O-acetyl-11-oxo-olean-12-en-30-nitrile

General Information

General Information Comment Organism
physiological function human carboxylesterase 2 (hCE2) plays important roles in the oral bioavailability and treatment outcomes of ester- or amide-containing drugs or prodrugs, such as anticancer agents CPT-11 (irinotecan) and LY2334737 (gemcitabine) Homo sapiens