Cloned (Comment) | Organism |
---|---|
into pcDNA3.1 for later transfections | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ankyrin-iPLA2s | iPLA2-splice variant, contributes to formation of the iPLA2-tetrameric complex but possesses no active site | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
cytoplasm | - |
Homo sapiens | 5737 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | one isoform of iPLA2 | Rattus norvegicus | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phospholipids + H2O | Rattus norvegicus | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? | |
phospholipids + H2O | Homo sapiens | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60733 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | iPLA2 | Homo sapiens | - |
heart | - |
Homo sapiens | - |
leukocyte | peripheral blood | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
spinal cord | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-palmitoyl-2-arachidonoylphosphatidylethanolamine | - |
Homo sapiens | 1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Rattus norvegicus | ? | - |
? | |
phospholipids + H2O | release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 88000 Da, homologous subunits, iPLA2 | Homo sapiens |