Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Streptococcus pyogenes | maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III | ? | - |
? | |
additional information | Streptococcus pyogenes SF370 | maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pyogenes | - |
M1 serotype | - |
Streptococcus pyogenes SF370 | - |
M1 serotype | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III | Streptococcus pyogenes | ? | - |
? | |
additional information | maturation of repeat/spacer-derived short crRNAs by RNase III and the CRISPR-associated Csn1 protein. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III | Streptococcus pyogenes SF370 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RNase III | - |
Streptococcus pyogenes |
General Information | Comment | Organism |
---|---|---|
physiological function | tracrRNA directs the maturation of repeat/spacer-derived short crRNAs by the activities of the widely conserved endogenous RNase III and the CRISPR-associated Csn1 protein. The maturation of crRNAs represents a key event in CRISPR activation, all components are essential to protect Streptococcus pyogenes against prophage-derived DNA. The co-processed tracrRNA and pre-crRNA carry short 3' overhangs reminiscent of cleavage by the endoribonuclease RNase III or the related eukaryotic Dicer and Drosha enzymes | Streptococcus pyogenes |