Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylcholine | stimulation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
F- | 50 mM, 90% inhibition | Rattus norvegicus | |
PCMB | 0.05 mM, 90% inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
phosphatidic acid | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | the largest portion of the activity is localized in the soluble fraction | Rattus norvegicus | 5829 | - |
lysosome | only 3% of the total activity | Rattus norvegicus | 5764 | - |
microsome | - |
Rattus norvegicus | - |
- |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus | |
Mn2+ | slight stimulation | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
165 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dipalmitoyl-sn-glycerol 3-phosphate + H2O | - |
Rattus norvegicus | 1,2-dipalmitoyl-sn-glycerol + phosphate | - |
? | |
1-acyl-sn-glycerol 3-phosphate + H2O | at 9.1% of the activity with phosphatidic acid | Rattus norvegicus | 1-acyl-sn-glycerol + phosphate | - |
? | |
5'-AMP + H2O | 8.6% of the activity with phosphatidic acid | Rattus norvegicus | ? | - |
? | |
ATP + H2O | 7.2% of the activity with phosphatidic acid | Rattus norvegicus | ? | - |
? | |
Glucose 6-phosphate + H2O | at 5.2% of the activity with phosphatidic acid | Rattus norvegicus | Glucose + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Rattus norvegicus | 1,2-diacyl-sn-glycerol + phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 7.6 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.2 | 8.2 | pH 7.2: 76% of maximal activity, pH 8.2: 74% of maximal activity | Rattus norvegicus |