Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Borreliella burgdorferi | |
Zn2+ | - |
Borreliella burgdorferi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | may substitute for Mn2+ | Borreliella burgdorferi | |
Mn2+ | maximum activity is observed with Mn2+ as a cofactor | Borreliella burgdorferi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Borreliella burgdorferi | O51564 | - |
- |
Borreliella burgdorferi DSM 4680 | O51564 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic di-3',5'-adenylate + H2O | - |
Borreliella burgdorferi | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
cyclic di-3',5'-adenylate + H2O | - |
Borreliella burgdorferi DSM 4680 | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PdeA is a DHH-DHHA1 domain protein | Borreliella burgdorferi |
Synonyms | Comment | Organism |
---|---|---|
BB0619 | - |
Borreliella burgdorferi |
Dhhp | - |
Borreliella burgdorferi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Borreliella burgdorferi |
General Information | Comment | Organism |
---|---|---|
physiological function | DhhP is essential for Borrelia burgdorferi growth both in vitro and in the mammalian host. The conditional DhhP mutant has a dramatic increase in intracellular c-di-AMP level in comparison to the isogenic wild-type strain. Elevated cellular c-di-AMP in Borrelia burgdorferi does not result in an increased resistance to beta-lactamase antibiotics. The DhhP mutant is defective in induction of the sigmaS factor, RpoS, and the RpoS-dependent outer membrane virulence factor OspC | Borreliella burgdorferi |