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Literature summary for 3.1.4.59 extracted from
- Cross-talk between two nucleotide-signaling pathways in Staphylococcus aureus (2015), J. Biol. Chem., 290, 5826-5839 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| guanosine pentaphosphate | c-di-AMP phosphodiesterase GdpP is inhibited in a dose-dependent manner by ppGpp | Staphylococcus aureus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gdpP | - |
Staphylococcus aureus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1297 | - |
guanosine pentaphosphate | pH 8.5, temperature not specified in the publication | Staphylococcus aureus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Staphylococcus aureus | GdpP is expressed constitutively throughout growth | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | GdpP mutant bacteria contain extra-membranous material at the division sites and in the form of vesicles in the cytoplasm. Expression of superoxide dismutase SodM is 5fold downregulated in the mutant, while no significant differences in the susceptibility to H2O2 or in peroxide levels are observed | Staphylococcus aureus |
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