Literature summary for 3.1.4.59 extracted from

Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus (2016), J. Biol. Chem., 291, 26970-26986 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
guanosine pentaphosphate	-	Staphylococcus aureus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Staphylococcus aureus	5737	-

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	A0A0H2XFX6	-	-
Staphylococcus aureus USA300	A0A0H2XFX6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclic di-3',5'-adenylate + H2O	-	Staphylococcus aureus	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?
cyclic di-3',5'-adenylate + H2O	-	Staphylococcus aureus USA300	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?
additional information	isoform Pde2 is capable of hydrolyzing c-di-AMP and Pde2 preferentially converts linear 5'-phosphonoadenylyl-adenosine (pApA) to AMP, reaction of EC 3.1.3.7. No substrate: ATP	Staphylococcus aureus	?	-	?
additional information	isoform Pde2 is capable of hydrolyzing c-di-AMP and Pde2 preferentially converts linear 5'-phosphonoadenylyl-adenosine (pApA) to AMP, reaction of EC 3.1.3.7. No substrate: ATP	Staphylococcus aureus USA300	?	-	?

Synonyms

Synonyms	Comment	Organism
PDE2	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	a Pde2 mutant strain displays a growth defect in the early growth phase. Mutation leads to an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased resistance to oxacillin	Staphylococcus aureus

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Release 2023.1 (January 2023)