Literature summary for 3.1.4.59 extracted from

Witte, C.E.; Whiteley, A.T.; Burke, T.P.; Sauer, J.D.; Portnoy, D.A.; Woodward, J.J.
Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection (2013), mBio, 4, e00282 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	transmembrane protein	Listeria monocytogenes	16020	-

Organism

Organism	UniProt	Comment	Textmining
Listeria monocytogenes	Q8YAR3	-	-
Listeria monocytogenes ATCC BAA-679	Q8YAR3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclic di-3',5'-adenylate + H2O	-	Listeria monocytogenes	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?
cyclic di-3',5'-adenylate + H2O	-	Listeria monocytogenes ATCC BAA-679	5'-O-phosphonoadenylyl-(3'->5')-adenosine	-	?

Synonyms

Synonyms	Comment	Organism
Lmo0052	-	Listeria monocytogenes
PdeA	-	Listeria monocytogenes

General Information

General Information	Comment	Organism
physiological function	overexpression of PdeA leads to marked decreases in growth rates, both in vitro and in infected macrophages. Deletion of pdeA affects bacterial response to acid stress and leads to increased expression of resuscitation-promoting factors. Mutants with altered levels of c-di-AMP have different susceptibilities to peptidoglycan-targeting antibiotics	Listeria monocytogenes

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Release 2023.1 (January 2023)