Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
D130A/H131A | mutant fails to hydrolyze c-di-AMP | Mycobacterium tuberculosis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mycobacterium tuberculosis | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P71615 | bifunctional oligoribonuclease and PAP phosphatase, cf. EC 3.1.3.7. Enzyme has a DHH/DHHA1 domain | - |
Mycobacterium tuberculosis H37Rv | P71615 | bifunctional oligoribonuclease and PAP phosphatase, cf. EC 3.1.3.7. Enzyme has a DHH/DHHA1 domain | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic di-3',5'-adenylate + H2O | - |
Mycobacterium tuberculosis | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
cyclic di-3',5'-adenylate + H2O | - |
Mycobacterium tuberculosis H37Rv | 5'-O-phosphonoadenylyl-(3'->5')-adenosine | - |
? | |
additional information | enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 | Mycobacterium tuberculosis | ? | - |
? | |
additional information | enzyme has c-di-AMP specific phosphodiesterase activity. It hydrolyzes c-di-AMP to 5'-AMP in two steps. First, it linearizes c-di-AMP into pApA , reaction of EC 3.1.4.59, which is further hydrolyzed to 5'-AMP, reaction of EC 3.1.4.60 | Mycobacterium tuberculosis H37Rv | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NrnA | - |
Mycobacterium tuberculosis |
Rv2837c | - |
Mycobacterium tuberculosis |